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当前位置: 首页 > 文章 > 香青兰总黄酮对心肌缺血-再灌注损伤线粒体保护作用的研究 石河子大学学报(自然科学版) 2015,33 (5) 599-603
Position: Home > Articles > Studies on Mitochondrial of Dracocephalum Moldavica L. Flavonoids against Myocardial Ischemia / Reperfusion Injury in Rats Journal of Shihezi University(Natural Science) 2015,33 (5) 599-603

香青兰总黄酮对心肌缺血-再灌注损伤线粒体保护作用的研究

作  者：
姚佳茗;曹文疆;袁勇;洪叶;陈卫军;王新春
单  位：
石河子大学医学院第一附属医院;石河子大学药学院
关键词：
香青兰总黄酮;心肌缺血-再灌注损伤;线粒体;保护作用
摘  要：
为研究香青兰总黄酮(TFDM)对大鼠急性心肌缺血-再灌注损伤(MIRI)线粒体的保护作用。采用结扎大鼠左冠状动脉前降支的方法复制MIRI的模型的方法。测定心肌梗死程度和心肌组织内ATP的含量,电镜观察线粒体超微结构变化,检测线粒体活性。结果显示,与模型组比较,TFDM不仅能够明显减轻大鼠心肌梗死程度,提高心肌ATP含量,还能有效保护线粒体的结构完整性,并且TFDM能够显著升高线粒体活性(P<0.05或P<0.01)。由此可知,TFDM具有保护缺血-再灌注损伤的心肌组织以及线粒体的作用。
译  名：
Studies on Mitochondrial of Dracocephalum Moldavica L. Flavonoids against Myocardial Ischemia / Reperfusion Injury in Rats
作  者：
YAO Jiaming;CAO Wenjiang;YUAN Yong;HONG Ye;CHEN Weijun;WANG Xinchun;School of Pharmacy,Shihezi University;The First Affiliated Hospital,School of Medicine,Shihezi University;
关键词：
Dracocephalum Moldavica L.total flavonoids,Myocardial Ischemia / Reperfusion Injury,mitochondria,protective effects
摘  要：
To investigate the protective effects of Dracocephalum Moldavica L. total flavonoids(TFDM) in the aspect of mitochondria against Myocardial Ischemia/Reperfusion Injury(MIRI). MIRI model was induced by ligating of anteriordescending of left coronary artery in rats. Infarct size were observed by Evans Blue- TTC staining and concentration of ATP of myocardial were measured. The ultrastructure of mitochondria were observed by electron microscopic and activity of mitochondria were measured. Compared with the I/R group, the TTC staining revealed that the degree of myocardial infarction reduced significantly of TFDM groups, the levels of ATP of myocardium were raised by TFDM, also TFDM have protected the ultrastructure of mitochondria. Meanwhile, TFDM showed significantly increase in the effect of activity of mitochondria(P<0.05 orP<0.01).TFDM had protective effect about myocardium and mitochondria.

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