中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > Motilin基因单核苷酸多态性与奶牛真胃变位易感性的关联分析 中国奶牛 2015 (9) 1-4
Position: Home > Articles > Association Between a Single Nucleotide Polymorphism in the Motilin Gene and Abomasal Displacement in Dairy Cattle China Dairy Cattle 2015 (9) 1-4

Motilin基因单核苷酸多态性与奶牛真胃变位易感性的关联分析

作  者：
陆璐;黄河天;郭刚;李锡智;马翀;刘林;王雅春;俞英;孙东晓;张胜利;曹杰;张毅
单  位：
中国农业大学动物科技学院;北京首农畜牧发展有限公司;中国农业大学动物医学院
关键词：
中国荷斯坦牛;MLN基因;真胃变位;Cochran-Armitage趋势检验;PCR-RFLP
摘  要：
以北京地区11个牧场的494头中国荷斯坦牛为试验材料,采用病例-对照(case-control)设计,研究了motilin(MLN)基因第一外显子内转录因子结合位点g.90T>C多态性与奶牛真胃变位易感性的关联。结果共检测到TT、TC、CC三种基因型,基因型频率分布符合Hardy-Weinberg平衡(P>0.05)。将该位点3种基因型与真胃变位易感性进行关联分析,结果发现在一胎牛中关联显著(Cochran-Armitage趋势检验P<0.05;卡方检验P=0.09);与基因型TT相比,基因型TC和CC的比值比(OR值)分别为1.52和2.06,即易感性CC>TC>TT,显示C等位基因更易导致真胃变位。这些结果支持了MLN基因与荷斯坦牛真胃变位可能存在密切的关系。对g.90T>C位点T等位基因的选择,将有利于提高群体对真胃变位的遗传抗性。
译  名：
Association Between a Single Nucleotide Polymorphism in the Motilin Gene and Abomasal Displacement in Dairy Cattle
作  者：
LU Lu;HUANG He-tian;GUO Gang;LI Xi-zhi;MA Chong;LIU Lin;WANG Ya-chun;YU Ying;SUN Dong-xiao;ZHANG Sheng-li;CAO Jie;ZHANG Yi;College of Animal Science and Technology, China Agricultural University;Beijing Shounong Xumu Co., Ltd.;College of Veterinary Medicine, China Agricultural University;
关键词：
Chinese Holstein;;MLN gene;;Abomasal displacement;;Cochran-Armitage trend test;;PCR-RFLP
摘  要：
The association between a transcription factor binding site polymorphism(g.90T>C) in the exon 1 of bovine MLN gene and abomasal displacement in dairy cattle was investigated using a case-control design. A total of 494 Chinese Holstein cows were collected from 11 herds in Beijing. Three kinds of genotypes(TT, TC, CC) were identified and no significant departure from Hardy-Weinberg equilibrium was detected(P>0.05). Significant association between the SNP and abomasal displacement was found for the first lactation cows(Cochran-Armitage trend test P<0.05; chi-square test P=0.09). Odds ratios(OR) for TC and CC were 1.52 and 2.06, respectively, with TT as reference, indicating the increasing susceptibility of cows with TT, TC, and CC. These results suggested a significant genetic association between MLN gene and abomasal displacement in Chinese Holstein cattle. Selection for the favorable T allele of g.90T>C could potentially improve genetic resistance to abomasal displacement.

相似文章

导出引用
计量
文章访问数: 9
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46