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Position: Home > Articles > Effects of Chanfukang(Chinese Medicine) on the Cytokine Level of Immunosuppressive Mouse Journal of Anhui Agricultural Sciences 2009,37 (13) 208-209

中药产复康对免疫功能低下小鼠细胞因子的影响

作  者:
米宝明;严作廷;宗瑞谦;王东升;杨国林;谢家声;李世宏;梁纪兰
单  位:
甘肃农业大学动物医学院;中国农业科学院兰州畜牧与兽药研究所
关键词:
产复康;IL-1β;IL-2;TNFα
摘  要:
[目的]研究产复康对免疫功能低下小鼠细胞因子的影响,为进一步研究其对机体免疫功能的影响提供基础。[方法]通过给小鼠2次皮下注射40 mg/kg体重的环磷酰胺,建立免疫抑制模型,并分别以10、15、20 g/kg的剂量灌服产复康,检测小鼠血清中细胞因子IL-1β、IL-2和TNFα水平的变化。[结果]单一灌服产复康明显提高了正常小鼠血清中的IL-1β、IL-2和TNFα水平;环磷酰胺降低了小鼠血清中IL-1β、IL-2和TNFα水平;产复康显著提高免疫抑制小鼠血清中IL-1β、IL-2和TNFα水平。[结论]产复康能拮抗环磷酰胺的免疫抑制,提高机体的免疫功能。
译  名:
Effects of Chanfukang(Chinese Medicine) on the Cytokine Level of Immunosuppressive Mouse
作  者:
MI Bao-ming et al (Animal Medical College,Gansu Agricultural University,Lanzhou,Gansu 730070)
关键词:
Chanfukang;IL-1β;IL-2;TNF α
摘  要:
[Objective] The research aimed to study the effects of Chanfukang on the cytokines of immunosuppressive mice,providing the basis for the further research of its effects on immune function.[Method] Immunosuppressive mouse model was established through twice intraperitoneal injection with cyclophosphamide at the dose of 40 mg/kg.After the mice were gavaged respectively with Chanfukang at the dose of 10,15 and 20 g/kg,the level of cytokines(IL-1β,IL-2 and TNF α) were detected.[Result] Chanfukang significantly increased the level of IL-1β,IL-2 and TNF α in the serum of mice gavaged only with Chanfukang;the level of IL-1β,IL2 and TNF α was inhibited in mice treated with cyclophosphamide;Chanfukang significantly increased the level of IL-1β,IL-2 and TNF α in the serum of immunosuppressive mice.[Conclusion] Chanfukang should antagonize the immunosuppression of cyclophosphamide and improve the immune function.

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