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Position: Home > Articles > Overview of Ovine Induced Pluripotent Stem Cells(iPSCs) Heilongjiang Journal of Animal Reproduction 2016,24 (3) 3-7

羊诱导多能性干细胞研究概况

作  者:
豆兴堂;李万波;王家明;杨秋凤
单  位:
辽宁省畜牧科学研究院
关键词:
羊;体细胞重编程;诱导多能干细胞
摘  要:
体细胞重编程是产生干细胞的重要途径。体细胞内导入特定的诱导因子,可将其重编程为诱导多潜能干细胞(induced pluripotent stem cells,iPSCs),iPSCs同胚胎干细胞(embryonic stem cells,ESCs)一样具有自我更新并维持未分化状态的能力。利用小分子化合物组合进行体细胞重编程,使iPSCs技术向安全应用更近一步。羊方面已经获得了iPSCs,并生产出了iPSCs嵌合羊。本文主要从体细胞重编程、iPSCs诱导方法、诱导因子和iPSCs鉴定研究现状作一综述。
译  名:
Overview of Ovine Induced Pluripotent Stem Cells(iPSCs)
作  者:
DOU Xing-tang;LI Wang-bo;WANG Jia-ming;YANG Qiu-feng;Institute of Animal husbandry of Liaoning province;
关键词:
Ovine;;Somatic cell reprogramming;;Induced pluripotent stem cells(iPSCs)
摘  要:
Somatic cell reprogramming was important way of produced stem cell. Induced pluripotent stem cells( iPSCs) can be generated from somatic cells by ectopic- expression of specific inducing factors,which are capable of maintaining self- renewal and an undifferentiated state just like embryonic stem cells( ESCs). The technique of iPSCs will be close to safe application by used a number of small- molecule compounds aiming at replacing some transcription factors, reprogramming somatic cell and finally succeeding in obtaining iPSCs completely induced by a group of chemicals without any genetic manipulation. Some researchers have obtained iPSCs and also generated chimera of lambs on ovine iPSCs reseach. This review presents a general progress on somatic cell reprogramming,the inducing methods,the inducing factors as well as the research status of identifying iPSCs.

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