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当前位置: 首页 > 文章 > 番木瓜种子中异硫氰酸苄酯(BITC)的抑癌试验 热带生物学报 2012,3 (2) 130-134
Position: Home > Articles > Test of Tumor-inhibition of Benzyl Isothiocyanate(BITC)in Papaya Seed Journal of Tropical Biology 2012,3 (2) 130-134

番木瓜种子中异硫氰酸苄酯(BITC)的抑癌试验

作  者：
周骊;李泽友;沈文涛;靳云奎;周鹏
单  位：
海南医学院;中国热带农业科学院热带生物技术研究所;海南省农垦中学
关键词：
番木瓜;种子提取物;异硫氰酸苄酯;MTT法;肿瘤抑制
摘  要：
利用MTT法检测番木瓜种子中的异硫氰酸苄酯(BITC)在体外对肝癌细胞等6种常见癌细胞的生长抑制率。结果表明,番木瓜种子提取物中BITC的浓度达到5μmol.L-1(相当于0.745mg.L-1)时,对人肝癌HepG2细胞、人肺癌A549细胞、人乳腺癌MCF-7细胞、人大肠癌HCT-8细胞、人宫颈癌HeLa细胞、人前列腺癌DU-145细胞的生长抑制率均达到70%以上,其中,人肝癌细胞HepG2最敏感,cBITC=2.5μmol.L-1时抑制率可达87%,在cBITC=10μmol.L-1和5.0μmol.L-1时,人大肠癌HCT-8细胞的生长抑制率几乎相同。因此,BITC具有良好的抑癌效果。
译  名：
Test of Tumor-inhibition of Benzyl Isothiocyanate(BITC)in Papaya Seed
作  者：
ZHOU Li 1,LI Ze-you 2,SHEN Wen-tao 3,JIN Yun-kui 1,ZHOU Peng 3(1.Hainan Nongken Middle School,Haikou 570226,China;2.Hainan Medical University,Haikou 571101,China;3.Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China)
关键词：
Carica papaya L.;seed extract;benzyl isothiocyanate;MTT method;tumor-inhibition
摘  要：
Benzyl isothiocyanate(BITC) was extracted from papaya seeds(Carica papaya L.) and used to determine its inhibitory effect on the cell growth of 6 common cancers in vitro including liver cancer by using the MTT method.The results showed the papaya seed extract with BITC at the concentration of up to 5 μmol.L-1(equivalent to 0.745 mg.L-1) inhibited more than 70% of the cell growth of a human liver cancer cell line HepG2,a lung cancer cell line A549,a breast cancer cell line MCF-7,a colon cancer cell line HCT-8,a cervical cancer cell line Hela and a prostate cancer cell line DU-145.Of them the HepG2 liver cancer cells were the most sensitive to BITC which gave an 87% inhibition over the cells at the concentration 2.5 μmol.L-1.HCT-8 colon cancer cells had a similar inhibition rate when treated with BITC at both 5.0 and 10 μmol.L-1.This showed that higher concentration of BITC in the extract of papaya seeds was similar to the lower concentration(5.0 μmol.L-1) in inhibition of the growth of the cancer cells.

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