当前位置: 首页 > 文章 > 复方中药制剂对小鼠的急性毒性试验 中国畜牧兽医 2007,34 (6) 112-113
Position: Home > Articles > Acute Toxicity Experiments of Chinese Herbal Compound on Mice China Animal Husbandry & Veterinary Medicine 2007,34 (6) 112-113

复方中药制剂对小鼠的急性毒性试验

作  者:
陈忠伟;刘伟;赵武
单  位:
广西兽医研究所
关键词:
复方中药制剂;小鼠;急性毒性;LD50
摘  要:
为进一步临床试验和了解复方中药制剂的安全性,对其进行了小鼠的急性毒性试验。将100只昆明小鼠分为10组,3组口服试验中,给药剂量分别为6667、10000、15000 mg/kg体重时,小鼠仍健活;腹腔注射试验分为6组,给药剂量分别为10000、12000、14400、17280、20740、24880 mg/kg体重,计算半数致死量LD50=16660 mg/kg,说明该药安全无毒。
译  名:
Acute Toxicity Experiments of Chinese Herbal Compound on Mice
作  者:
CHEN Zhong-wei,LIU Wei,ZHAO Wu(Veterinary Research Institute of Guangxi,Nanning 530001,China)
关键词:
chinese herbal compound;mice;acute toxicity;LD50
摘  要:
In order to study the clinical effect and the acute toxicity of Chinese herbal compound,a total of 100 mice were divided into 10 groups,3 groups of which were orally given Jinhua by 6667,10000 and 15000 mg per kilogram body weight respectively,and 6 groups of which were celiacly injected Jinhua by 10000,12000,14400,17280,20740 and 24880 mg per kilogram body weight respectively.The results showed that,even orally given Chinese herbal compound Jinhua by 15000 mg per kilogram body weight to the mice,not any toxicity or side-effect were observed.The LD50 of celiac dosage of Chinese herbal compound was 16660 mg per kilogram body weight.The results indicate that the Chinese herbal compound is safe.

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