Position: Home > Articles > Effect of Fibrinolytic Compound on Fibrinolysis in Rats
FOOD SCIENCE
2009,30
(23)
410-414
纤溶化合物促进大白鼠肺血栓溶解作用的研究
作 者：
瞿佳华;田宏;吴文惠;郝斐;包斌
单 位：
赤峰制药股份有限公司;上海海洋大学食品学院
关键词：
肺血栓动物模型;MTP;组织切片;SDS-PAGE;纤溶作用
摘 要：
利用异硫氰酸荧光素标记的纤维蛋白建立大白鼠肺血栓模型,将一种纤溶促进化合物MTP从尾静脉注射于肺血栓大白鼠,观察肺组织切片和检测血浆中异硫氰酸荧光素-纤维蛋白的降解状况。发现化合物MTP有促进实验动物肺血栓的溶解作用,推测化合物MTP的添加提高了纤溶因子的纤溶活性。
译 名：
Effect of Fibrinolytic Compound on Fibrinolysis in Rats
作 者：
QU Jia-hua1,TIAN Hong2,WU Wen-hui1,HAO Fei1,BAO Bin1,* (1. College of Food Science and Technology, Shanghai Ocean University, Shanghai 200090, China ; 2 Chifeng Pharmaceutical Co. Ltd., Chifeng 024001, China)
关键词：
pulmonary thrombotic model;MTP;histological section;SDS-PAGE;fibrinolysis
摘 要：
The effect of compound MTP on induced clotlysis and its possible mechanism were investigated on the experimental model of pulmonary thrombosis in rat with fibrin labeled with FITC. The histological specimens of rat lung tissue were prepared and the degradation of FITC-labeled fibrin was analyzed by SDS-PAGE. The results showed that MTP was able to enhance fibrinolysis in vivo. It was speculated that compound MTP could enhance intrinsic activity of prourokinase as a plasminogen activator in a rat pulmonary embolism model.
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