Zeping Xu;Jiang Lin-la

Department of Medical Research,Guangzhou Military General Hospital,Guangzhou,Guangdong 510010,China;Department of Medical Research,Guangzhou Military General Hospital,Guangzhou,Guangdong 510010,Chin

231;mb;mda;ginkgo biloba extract;tea polyphenols;human breast cancer cell lin

[Objective] To observe the combination effects of tea polyphenols and Ginkgo Biloba extract on proliferation of human breast cancer cell line MDA-MB-231.[Methods] Effects of tea polyphenols and Ginkgo Biloba extract and their combination on human breast cancer cell line MDA-MB-231 were detected by MTT assay,and cell morphological analysis was employed to examine the morphological changes of MDA-MB-231 in all test groups.[Results] The inhibition rate of Ginkgo Biloba extract combined with tea polyphenols at low concentration(10,20 μg/ml) was the highest,and the synergistic effect of joint group on breast cancer cell worked in a certain range;in addition,human breast cancer cell line MDA-MB-231 was in poor state and had weak refraction rate in joint group;adherent cells was shrunk and became round by comparison with that in tea ployphenols group,Ginkgo Biloba and control group.[Conclusion] Ginkgo Biloba extract at low concentration had poor inhibitory effect on human breast cancer cell line MDA-MB-231.Tea polyphenols and joint group can inhibit the growth of MDA-MB-231,and the joint effects of tea polyphenols and Ginkgo Biloba extract are synergistic within a certain range.