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Position: Home > Articles > Research progress in the treating methods of Toxoplasma gondii infection Heilongjiang Animal Science and Veterinary Medicine 2016 (5) 54-57+61

弓形虫感染治疗方法的研究进展

作  者:
王大为;郭晓改;司海洋;穆名扬;李红魁
单  位:
辽宁省农业科学院;沈阳农业大学畜牧兽医学院辽宁省农业经济学校辽宁省动物疫病预防控制中心本溪市动物疫病预防控制中心;沈阳农业大学;辽宁省动物疫病预防控制中心
关键词:
弓形虫;治疗;药物;感染;叶酸;乙胺嘧啶;磺胺嘧啶
摘  要:
弓形虫病是一种人畜共患寄生虫病,全球有1/3~1/2的人感染该疾病。弓形虫感染的临床表现各不相同,这种差异取决于宿主基因、寄生虫基因、宿主免疫状态、感染量及感染时寄生虫发育状态,这些因素仅是临床症状差异的部分原因。一些急性感染(如在婴儿期和胎儿期感染,大龄儿童、成人或者免疫功能低下者的严重感染),如治疗及时,可被有效治愈。妊娠期孕妇要进行血清学检测来诊断该病,目的是为了便于在胎儿期和婴儿期进行治疗。一种无毒副作用可以消灭速殖子和缓殖子的药物和一种能防治该疾病的疫苗是全人类未来的共同需要。
译  名:
Research progress in the treating methods of Toxoplasma gondii infection
作  者:
WANG Dawei;GUO Xiaogai;SI Haiyang;MU Mingyang;LI Hongkui;LI Dechen;ZHANG Guoxing;YUAN Gaoming;XING Meng'en;YANG Na;College of Animal Science and Veterinary Medicine,Shenyang Agricultural University;Liaoning Agricultural Economic School;Liaoning Center for Animal Disease Control and Prevention;Benxi Center for Animal Disease Control and Prevention;
关键词:
Toxoplasma gondii;;treatment;;drug;;infection;;folate;;pyrimethamine;;sulfadiazine
摘  要:
Toxoplasmosis is a zoonotic parasitic disease,and 1 /3 to 1 /2 of all people worldwide have been infected with the disease. Clinical manifestations of Toxoplasma gondii infections vary depending on host gene,parasite gene,host immune status,the amount of infection,and the developmental state of parasite when infecting its host; however,these factors are due in part to differences in clinical symptoms. Some acute infections,such as infections in the fetal and infancy periods,severe infections in elder children,adults or immunocompromised persons,can be effectively cured when promptly treated. A serological testing in pregnant women should be conducted during gestation to diagnose toxoplasmosis,in order to facilitate the treatment of toxoplasmosis in the fetal and infancy periods. A kind of drug without toxic side effects to eliminate Toxoplasma gondii tachyzoites and bradyzoites,and a kind of vaccine to prevent toxoplasmosis are mankind's common needs in the future.

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