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当前位置: 首页 > 文章 > 正交设计优化常山碱的醇提工艺 中兽医医药杂志 2015 (4) 44-46
Position: Home > Articles > Optimization of ethanol extraction process for febrifugine with orthogonal test Journal of Traditional Chinese Veterinary Medicine 2015 (4) 44-46

正交设计优化常山碱的醇提工艺

作  者：
郭志廷;梁剑平;刘宏;刘志国;徐海城
单  位：
中国农业科学院兰州畜牧与兽药研究所;中国农业科学院兰州畜牧与兽药研究所农业部兽用药物创制重点实验室甘肃省新兽药工程重点实验室石家庄正道动物药业有限公司
关键词：
常山;常山碱;乙醇回流;正交设计
摘  要：
目的:优化常山碱的乙醇回流提取工艺。方法:采用紫外-可见分光光度计测定常山碱含量,以浸膏得率和常山碱含量作为评价指标,应用正交设计法优化提取工艺参数。结果:常山碱乙醇回流提取最佳工艺:70%乙醇、提取时间1.5 h、溶媒用量7.5倍,提取2次,在此条件下,浸膏得率为10.43%,浸膏中常山碱含量为4.26%。方差分析表明,对常山碱提取率影响因素的大小顺序:提取次数>溶媒用量>提取时间>乙醇浓度。工艺验证试验表明,3批常山的平均浸膏得率和平均常山碱含量分别为11.27%和4.11%。结论:常山碱采用乙醇回流提取工艺切实可行,具有省时、操作简便和提取率高等优点。
译  名：
Optimization of ethanol extraction process for febrifugine with orthogonal test
作  者：
GUO Zhi-ting;LIANG Jian-ping;LIU Hong;LIU Zhi-guo;XU Hai-cheng;SHANG Ruo-feng;Key Laboratory of Veterinary Pharmaceutics Discovery, Ministry of Agriculture/Key Laboratory of New Animal Drug Project in Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS;Shijiazhuang Zhengdao Animal Pharmaceutical Co., Ltd;
关键词：
Dichroa febrifuga Lour.;;febrifugine;;ethanol refluxing process;;orthogonal test
摘  要：
Objective: To optimize ethanol refluxing process for febrifugine in Dichroa febrifuga Lour.. Methods: The conditions were optimized by orthogonal design, content of febrifugine was determined by ultraviolet-visible spectrophotometer, and content of febrifugine and extract yield were acted as the evaluation index. Results: The optimal process were using 70% of ethanol,extracted with 7.5 times of solvent twice(1.5 h per time); Extractum yield and febrifugine content were respectively up to 10.43%and 4.26% under above condition. Variance analysis showed that the extraction rate was affected on following: extraction times,dosage of solvent, extraction time and ethanol concentration. The process validation showed that average extract yield and content of febrifugne of three groups were 11.27% and 4.11%, respectively. Conclusion: Febrifugine extraction is feasible by ethanol refluxing process, which has advantages of time-saving, energy conservation and higher extraction rate.

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