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啶氧菌酯的合成工艺优化

作  者:
李爱军;雷玉马
单  位:
河北省药用分子化学重点实验室-省部共建国家重点实验室培育基地;河北科技大学化学与制药工程学院
关键词:
啶氧菌酯;杀菌剂;合成
摘  要:
[目的]研究新型杀菌剂啶氧菌酯的合成工艺。[方法]以邻甲基苯乙酸为原料,经酯化、酯缩合、甲基化、氯化、醚化反应5步合成啶氧菌酯。[结果]在优化的反应条件下,总收率44.2%,纯度99%。[结论]该工艺收率高、操作简便、产品纯度高,适合工业化生产。
译  名:
Synthesis of Picoxystrobin
作  者:
LI Ai-jun;LEI Yu-ma;College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology;State Key Laboratory Breeding Base-Key Laboratory of Molecular Chemistry for Drug of Hebei Province;
关键词:
picoxystrobin;;fungicide;;synthesis
摘  要:
[Aims] This paper aims tooptimize and improve the synthetic process of picoxystrobin. [Methods] Picoxystrobin was synthesized via esterification, ester condensation, methylation, chloration and etherification from o-tolylacetic acid.[Results] Under the optimal conditions, the total yield was 44.2% based on o-tolylacetic acid and the purity was 99%.[Conclusions] The process has some advantages of high yield, simple operation and high purity, which is suitable for industrial manufacture.

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