中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 中草药对复方新诺明在大菱鲆体内残留消除的影响 农业环境科学学报 2008,27 (05) 2096-2100
Position: Home > Articles > Effect of Chinese Herbal Medicine on Residue Elimination of Compound Sulfamethoxazole in Turbot (Scophthatmus maximus) Journal of Agro-Environment Science 2008,27 (05) 2096-2100

中草药对复方新诺明在大菱鲆体内残留消除的影响

作  者：
张海珍;李健;王群;刘淇;周一兵
单  位：
中国水产科学研究院;大连水产学院生命科学与技术学院
关键词：
复方新诺明;大菱鲆;中草药;残留
摘  要：
采用高效液相色谱法研究了复方新诺明在大菱鲆体内的残留消除规律,探讨了饲料中添加中草药对其残留消除的影响。健康大菱鲆随机分成2组,对照组和试验组连续5d投喂复方新诺明药饵,从第6d起对照组投喂不含药物的空白饵料,试验组投喂中药三黄散药饵,连续投喂1个月。定期取样,测定复方新诺明残留情况。结果表明,在(10±2)℃水温下,两种主要成分磺胺甲基异噁唑和甲氧苄啶在大菱鲆血清、肌肉、肝脏中的消除半衰期如下:对照组为T1/2β血清7.86d和9.30d、T1/2β肌肉8.42d和17.46d、T1/2β肝脏10.93d和20.63d;试验组为T1/2β血清7.54d和8.76d、T1/2β肌肉7.42d和16.11d、T1/2β肝脏10.40d和18.63d。以可食性组织肌肉为残留靶组织,磺胺甲基异噁唑和甲氧苄啶消除到最高残留限量(0.01μg·mL-1和0.05μg·mL-1)以下,对照组需要61d和41d,试验组需要46d和26d,表明中药三黄散对复方新诺明在大菱鲆体内的消除具有一定的促进作用。
译  名：
Effect of Chinese Herbal Medicine on Residue Elimination of Compound Sulfamethoxazole in Turbot (Scophthatmus maximus)
作  者：
ZHANG Hai-zhen1,2, LI Jian2, WANG Qun2, LIU Qi2, ZHOU Yi-bing1 (1. College of Life Sciences and Biotechnology, Dalian Fisheries University, Dalian 116023, China; 2. YellowSea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China)
关键词：
compound sulfamethoxazole; turbot (Scophthatmus maximus); Chinese herbal medicine; residue
摘  要：
The tissues distribution, residue depletion of compound sulfamethoxazole and the influence of Chinese herbal medicine were investigated duringmultiple dosingin turbot at (10±2)°Cseawater. The healthy turbots were fed a medicated diet containing 2 500 mg·kg-1 compound sulfamethoxazole, twice daily for 5 days. Then the turbots were divided into two groups with different experimental diets. The con- trol group was fed a non- medicated diet, and the test group was fed a medicated diet containing 3 000 mg·kg-1 Chinese herbal medicine for one month. Serum, muscle and liver were sampled at different times and analyzed for sulfamethoxazole (SMZ) and trimethoprin (TMP) by high- performance liquid chromatography (HPLC). The results showed that the residual time of TMP in turbot was longer than SMZ. In serum, muscle and liver, the elimination half- lives of SMZ and TMP in the control group were 7.86 d and 9.30 d, 8.42 d and 17.46 d, 10.93 d and 20.63 d, and in the test group were 7.54 d and 8.76 d, 7.42 d and 16.11 d, 10.40 d and 18.63 d, respectively. The withdrawal period of SMZ and TMP were 61 d and 41 d in the control group, and 46 d and 26 d in the test group, respectively, when the concentrations in muscle fell belowthe maximum residue limits (MRLs) of 0.01 μg·mL-1 and 0.05 μg·mL-1. These results indicated that Chinese herbal medicine could promote elimination of compound sulfamethoxazole in turbot.

相似文章

导出引用
计量
文章访问数: 10
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46