作 者：
高丽英;尚海忠;张寿;宁鹏;常兰;陈长江
单 位：
青海省海西州兽医卫生监督所;青海大学农牧学院;青海省海西州动物疫预防病控制中心
摘 要：
[目的]研究牦牛胎盘粉对亚急性衰老小鼠心、肝、脾、肺、肾、骨骼肌中一氧化氮(NO)含量的影响。[方法]将健康小鼠随机分为正常对照组、模型组、阳性对照组、低海拔胎盘组、中海拔胎盘组和高海拔胎盘组,将除正常对照组外的其他5组用D-半乳糖,造亚急性衰老小鼠模型;然后对低、中和高海拔胎盘组的小鼠建模11 d后,每天灌胃牦牛胎盘粉,剂量为40 mg/kg。阳性对照组每天灌服维生素E 100 mg/kg,45 d后观察心、肝、脾、肺、肾组织中一氧化氮(NO)含量。[结果]高原牦牛胎盘粉可明显降低小鼠心、肝、脾、肺、肾组织中一氧化氮(NO)含量(P<0.01)。[结论]高原牦牛胎盘粉有很好的抗衰老作用。
译 名：
The Effect of Yak Placenta Powder on NO Content in Some Organs of Subacute Aging Model Mice
作 者：
GAO li-ying et al(Center of Animal Disease Control and Prevention,Haixi,Qinghai 817000)
关键词：
Yak;Placenta powder;Mice;Anti-aging effect;NO
摘 要：
[Objective] The purpose was to study the effect of yak placenta powder on NO content in heart,liver,spleen,lung and kidney,skeleton muscle of subacute aging model mice.[Method]The healthy mice were randomly divided into normal control group,model group,positive control group,low-elevation placenta group,middle-elevation placenta group and high-elevation placenta group.Five groups except for normal control group were used to construct subacute aging mice model by D-galactose.11 days later,the mice of the low-elevation,middle-elevation and high-elevation yak placenta powder groups were gastricly lavaged with yak placenta powder with its dose being of 400 mg/kg,respectively,positive control group were gastricly lavaged with Vitamin E100 mg/kg.After 45 days,the content of NO in heart,liver,spleen,lung and kidney,skeleton muscle were determinated.[Result] The results showed that yak placenta powder obviously decrease the content of NO in heart,liver,spleen,lung and kidney,skeleton muscle,indicating that the yak placenta powder has good anti-aging effect.
