Position: Home > Articles > Study on the toxicological effect of azaspiracid-1 (AZA1) on Hep-G2 cells
Heilongjiang Animal Science and Veterinary Medicine
2016
(17)
184-186+189+297
原多甲藻酸(AZA1)对Hep-G2细胞毒理作用的研究
作 者：
孙晓飞;宋大贺;丁健;刘淑艳;蒋丹;林长军
单 位：
辽宁出入境检验检疫局;大连机场出入境检验检疫局
关键词：
原多甲藻酸(AZA1);Hep-G2细胞;CCK-8;细胞浓度;细胞培养;毒理作用
摘 要：
为了研究原多甲藻酸(AZA1)的毒理作用,试验以Hep-G2细胞为作用对象,采用CCK-8细胞增殖-毒性检测试剂盒测定吸光度值,对不同浓度原多甲藻酸的毒理作用进行测定。结果表明:当原多甲藻酸浓度达到40 nmol/L时,对细胞毒理作用显现;当浓度达到60 nmol/L时,对细胞毒理作用显著。说明双壳贝类中一定量的原多甲藻酸会对人类健康产生影响。
译 名：
Study on the toxicological effect of azaspiracid-1 (AZA1) on Hep-G2 cells
作 者：
SUN Xiaofei;SONG Dahe;DING Jian;LIU Shuyan;JIANG Dan;LIN Changjun;Liaoning Entry -Exit Inspection and Qurantine Bureau;Dalian Airport Entry -Exit Inspection and Qurantine Bureau;
关键词：
azaspiracid-1(AZA1);;Hep-G2 cell;;CCK-8;;cell concentration;;cell culture;;toxicological effect
摘 要：
To study the toxicological effect of azaspiracid- 1( AZA1),Hep- G2 cells were used as action objects in the test. The toxicological effects of different AZA1 concentrations on Hep- G2 cells were determined by CCK- 8 cell proliferation and cytotoxity detection Kit for measuring absorbance values. The results showed that AZA1 had an obvious toxicological effect on Hep- G2 cells when its concentration reached 40 nmol/L,while AZA1 had a significant toxicological effect on Hep- G2 cells when its concentration reached 60 nmol/L. The result indicates that a certain amount of AZA1 in bivalves will affect mankind health.
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