当前位置: 首页 > 文章 > 饲料脂肪水平对大菱鲆幼鱼TOR信号通路的影响 水生生物学报 2017,41 (3) 491-496
Position: Home > Articles > EFFECTS OF DIETARY LIPID LEVELS ON TOR PATHWAY IN JUVENILE TURBOT(SCOPHTHALMUS MAXIMUS L.) Acta Hydrobiologica Sinica 2017,41 (3) 491-496

饲料脂肪水平对大菱鲆幼鱼TOR信号通路的影响

作  者:
唐卓懿;崔坤;陈强;谭朋;廖凯;麦康森;艾庆辉
单  位:
中国海洋大学教育部海水养殖重点实验室
关键词:
大菱鲆;脂肪水平;基因表达;磷酸化;TOR信号通路
摘  要:
研究旨在探究饲料脂肪水平对大菱鲆(Scophthalmus maximus)幼鱼雷帕霉素受体(TOR)信号通路的影响。以大菱鲆幼鱼[初始体重(8.6±0.01)g]为实验对象,配制脂肪水平分别为11.69%(适宜脂肪组)和16.58%(高脂组)的2种等氮饲料在室内循环水系统中进行投喂实验,养殖周期为97d。结果显示:(1)饲料脂肪水平升高对大菱鲆幼鱼存活和特定生长率(SGR)无显著影响(P>0.05)。(2)与适宜脂肪组相比,肝脏中TOR和4EBP1m RNA水平在高脂组上调(P<0.05)而4EBP2 m RNA水平在高脂组下调(P<0.05)。此外,与适宜脂肪组相比,肌肉中TOR和4EBP1 m RNA水平在高脂组下调(P<0.05)而4EBP2 m RNA水平在高脂组无显著变化。(3)饲料脂肪水平显著影响AKT、TOR和4EBPs磷酸化水平。肝脏中p-AKT(T308和S473)/AKT、p-m TOR(S2448)/m TOR和p-4EBP1(T37/46)/4EBP1在高脂组显著高于适宜脂肪组,而p-p70S6K(T389)/p70S6K在高脂组显著低于适宜脂肪组。肌肉中p-AKT(S473)/AKT、p-m TOR(S2448)/m TOR和p-4EBP1(T37/46)/4EBP1在高脂组显著低于适宜脂肪组,而p-p70S6K(T389)/p70S6K在高脂组显著高于适宜脂肪组。结果表明:大菱鲆幼鱼肝脏和肌肉TOR、4EBP1和4EBP2的m RNA表达量与AKT、TOR、4EBP1和p70 S6K磷酸化受到饲料脂肪水平调控,饲料脂肪水平升高,激活了肝脏TOR信号通路,同时肌肉TOR信号通路受到部分抑制。
译  名:
EFFECTS OF DIETARY LIPID LEVELS ON TOR PATHWAY IN JUVENILE TURBOT(SCOPHTHALMUS MAXIMUS L.)
作  者:
TANG Zhuo-Yi;CUI Kun;CHEN Qiang;TAN Peng;LIAO Kai;MAI Kang-Sen;AI Qing-Hui;The Key Laboratory of Mariculture (Ministry Education of China), Ocean University of China;
关键词:
Turbot;;Dietary lipid level;;Gene expression;;Phosphorylation;;TOR pathway
摘  要:
This study investigated the effects of dietary lipid levels on the TOR pathway in juvenile turbot using diets containing graded levels of lipid 11.69%(L11.69) and 16.58%(L16.58)(dry weight) to feed triple groups of juvenile turbot(8.6±0.01 g) for a 97 d trial. The lipids level in diet did not impact survival rate and SGR. Compared those in L11.69 group, L16.58 group increased the gene expression of TOR, 4EBP1 but decreased 4EBP2 in liver, and it increased the phosphorylation of p AKT-S473, p AKT-T308, pm TOR-S2448, and p4EBP1-T37/46. In the muscle, L16.58 group had decreased TOR and 4EBP1 associated with p AKT-S473, pm TOR-S2448 and p4EBP1-T37/46 compared with those in L11.69 group. In conclusion, L16.58 diet can activate TOR pathway in liver while partially suppress TOR pathway in muscle of junvenile turbot compare with L11.69 diet.

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