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脂滴在Beagle犬卵母细胞体外成熟中的研究

作  者:
胡敏华;黄妙容;周治东;倪庆纯;刘运忠
单  位:
广东温氏大华农生物科技有限公司;广州医药研究总院有限公司实验动物研究开发中心(国家犬类实验动物种子中心)
关键词:
Beagle犬;卵母细胞;体外成熟
摘  要:
犬排出的卵母细胞处于GV期,其体外成熟率在20%左右,尚未获得突破,阻碍了犬体外保种及基因修饰疾病模型创制研究。犬卵母细胞含有大量脂滴,关于脂滴与卵母细胞成熟的研究鲜有报道。综述了脂滴与犬卵母细胞体外成熟的关系,尝试寻找研究犬卵母细胞体外成熟新的突破口。
译  名:
Effect of Lipid Droplet on in Vitro Maturation of Beagle dogs
作  者:
HU Minhua;HUANG Miaorong;ZHOU Zhidong;NI Qingchun;LIU Yunzhong;Research and Development Center of Experimental Animal,Guangzhou General Pharmaceutical Research Institute Co.,Ltd.,(National Seed Center of Experimental Dog);Guangdong Wens Dahuanong Biotechnology Co.,Ltd.;
关键词:
beagle dogs;;oocytes;;in vitro maturation
摘  要:
Canine oocytes are ovulated in the germinal vesicle stage and undergo their maturation within the oviduct.At present, the in vitro maturation of the dogs are still unsatisfactory, less than 20% of canine oocytes achieve nuclear maturation in vitro, and the research progress of in vitro preservation and genetic modification of Beagle dogs were impeded to some extend.Although lipid droplets represent an abundant component in the oocyte cytoplasm, there are few research focuses on the relationship between lipid droplet and in vitro maturation of canine oocytes.This review summarized the research progress on the relationship between lipid droplet and in vitro maturation of canine oocytes.

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