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NF-κB信号通路在鱼类先天性免疫中的作用

作  者:
杨冰贞;张民;王克坚
单  位:
厦门大学近海海洋环境科学国家重点实验室
关键词:
NF-κB信号通路;鱼类;先天性免疫
摘  要:
NF-κB(nuclear factorκB)是一种广泛存在的核转录因子。经不同刺激信号激活后,参与多种免疫反应相关基因的表达调控,对鱼类先天性免疫调节起着十分重要的作用。对鱼类NF-κB的结构、功能及其信号传导途径进行概述,并对NF-κB信号通路在鱼类先天性免疫调节中的作用进行综述。
译  名:
Role of NF-κB Signal Pathway in the Innate Immune System of Fish
作  者:
Yang Bingzhen;Zhang Min;Wang Kejian;State Key Laboratory of Marine Environmental Science,Xiamen University;
关键词:
NF-κB signal pathway Fish Innate immune system
摘  要:
NF-κB(Nuclear factor κB)as an ubiquitously expressed nuclear transcription factor, involves in regulating the expression of immune-related genes after activation by a variety of stimuli and thus plays a very important role in the innate immune system of fish. It reviewed the structure, function and the signal pathway of fish NF-κB. Furthermore, we reviewed the role of NF-κB signal pathway in the innate immune system in fish.

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