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Position: Home > Articles > Study on Sterides Constituents of Bombyx Batryticatus Journal of Shihezi University(Natural Science) 2013,31 (6) 70-74

白僵蚕中甾体类化学成分的研究

作  者:
程锁明;王航宇;李国玉;黄健;王金辉
单  位:
沈阳药科大学中药学院;石河子大学药学院/新疆特种植物药资源重点实验室
关键词:
白僵蚕;甾体;结构鉴定
摘  要:
对白僵蚕的化学成分进行分离鉴定。采用溶剂提取、萃取、反复硅胶柱色谱、ODS、制备液相色谱法等方法进行分离纯化,根据化合物的理化性质和光谱数据鉴定其结构。结果从白僵蚕分离得到4个甾体类化合物,分别为5α,6α-环氧-(22E,24R)-麦角甾-8(14),22-二烯-3β,7α-二醇(1)、7α-甲氧基-(22E,24R)-5α,6α-环氧麦角甾-8(14),22-二烯-3β-醇(2)、(22E,24R)-麦角甾-5,7,22-三烯-3β-醇(3)、豆甾醇-7,22-二烯-3β,5α,6α-三醇(4),4个化合物均为首次从白僵蚕中分离得到。
译  名:
Study on Sterides Constituents of Bombyx Batryticatus
作  者:
CHENG Suoming;WANG Hangyu;LI Guoyu;HUANG Jian;WANG Jinhui;Key Laboratory of Phytomedicine Resources & Modernization of TCM/School of Pharmacy,Shihezi University;School of Traditional Chinese Medicine,Shenyang Pharmaceutical University;
关键词:
Bombyx Batryticatus;;steroid;;structure identification
摘  要:
To investigate the chemical constituentes of Bombyx Batryticatus.The compounds were isolated by means of solvent extraction,abstraction,chromatography on silica gel,ODS,preparative RP-HPLC.The structures were identified by spectral analysis and chemical evidence.Four compounds of steroid were isolated from the Bombyx Batryticatus,and were identified as 5α,6α-epoxy-(22E,24R)-ergosta-8(14),22-diene-3β,7α-diol(1),7α-methoxy-(22E,24R)-5α,6α-epoxyergosta-8(14),22-Dien-3β-ol(2),(22E,24R)-Ergosta-5,7,22-trien-3β-ol(3),stigmasta-7,22-diene-3β,5α,6α-triol(4).4compounds were isolated from Bombyx Batryticatus for the first time.

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