中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > Major vacuolar TPC1 channel in stress signaling: what matters, K(+), Ca(2+) conductance or an ion-flux independent mechanism? 逆境生物学(英文) 2022,2 (1)
Position: Home > Articles > Major vacuolar TPC1 channel in stress signaling: what matters, K(+), Ca(2+) conductance or an ion-flux independent mechanism? Stress Biology 2022,2 (1)

Major vacuolar TPC1 channel in stress signaling: what matters, K(+), Ca(2+) conductance or an ion-flux independent mechanism?

作  者：
Igor Pottosin;Oxana Dobrovinskay
单  位：
Foshan University;Biomedical Center, University of Colima, Colima, Mexic;Biomedical Center, University of Colima
关键词：
Calcium;Long-distance signaling;Potassium;TPC1;Vacuole;Voltage gatin
摘  要：
Two-pore cation channel, TPC1, is ubiquitous in the vacuolar membrane of terrestrial plants and mediates the long distance signaling upon biotic and abiotic stresses. It possesses a wide pore, which transports small mono- and divalent cations. K(+) is transported more than 10-fold faster than Ca(2+), which binds with a higher affinity within the pore. Key pore residues, responsible for Ca(2+) binding, have been recently identified. There is also a substantial progress in the mechanistic and structural understanding of the plant TPC1 gating by membrane voltage and cytosolic and luminal Ca(2+). Collectively, these gating factors at resting conditions strongly reduce the potentially lethal Ca(2+) leak from the vacuole. Such tight control is impressive, bearing in mind high unitary conductance of the TPC1 and its abundance, with thousands of active channel copies per vacuole. But it remains a mystery how this high threshold is overcome upon signaling, and what type of signal is emitted by TPC1, whether it is Ca(2+) or electrical one, or a transduction via protein conformational change, independent on ion conductance. Here we discuss non-exclusive scenarios for the TPC1 integration into Ca(2+), ROS and electrical signaling.

相似文章

导出引用
计量
文章访问数: 10
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46