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Position: Home > Articles > Advance in Studies on Glucagon-like Peptide-2 Chinese Journal of Animal Science 2007,43 (1) 44-47

胰高血糖素样肽-2的研究进展

作  者:
唐仁勇;陈代文;张克英;郭秀兰
单  位:
四川农业大学动物营养研究所
关键词:
胰高血糖素样肽-2;胃肠道;综述
摘  要:
胰高血糖素样肽-2(glucagon-like peptide-2,GLP-2)是一种胃肠道激素,由肠道的L细胞分泌,并在机体进食后释放入血。GLP-2对新生动物肠道发育具有特殊作用,GLP-2通过与GLP-2受体结合调节胃肠运动、胃酸分泌、肠內已糖转运,并且增强肠上皮细胞的屏障功能,这些使得GLP-2成为了现在消化生理领域的研究热点。本文主要从GLP-2的结构、生物学作用、作用机理及其分泌与降解等方面进行了综述。
译  名:
Advance in Studies on Glucagon-like Peptide-2
作  者:
TANG Ren-yong, CHEN Dai-wen, ZHANG Ke-ying, GUO Xiu-lan (Animal Nutrition Institute, Sichuan Agricultural University, Sichuan Ya'an 625014, China)
关键词:
GLP-2; gastrointestinal-tract; a review
摘  要:
GLP-2 is a 33-amino acid peptide secreted from L cells of the small intestine. GLP-2 plays a key role in the development of gastrointestinal-tract of neonatal animal. GLP-2 regulates gastric motility, gastric acid secretion, intestinal hexose transport, and increases the barrier function of the gut epithelium. The actions of GLP-2 are transduced by the GLP-2 receptor, a G protein-coupled receptor. These make GLP-2 become an important hormone in physiology. The structure, physiological effect, mechanism of action, secretion and degradation of GLP-2 were summarized in the article.

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