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当前位置: 首页 > 文章 > 亚麻籽油对链脲佐菌素诱导大鼠糖尿病肾病的保护作用 食品科学 2020 (3) 120-126
Position: Home > Articles > Protective Effect of Flaxseed Oil on Diabetic Nephropathy Induced by Streptozocin in Rats FOOD SCIENCE 2020 (3) 120-126

亚麻籽油对链脲佐菌素诱导大鼠糖尿病肾病的保护作用

作  者：
牛佳卉;付梦琪;周茜;王亚旭;吴梦颖;赵文;王颉
单  位：
河北农业大学食品科技学院河北省农产品加工工程技术中心
关键词：
亚麻籽油;链脲佐菌素;糖尿病肾病;保护作用
摘  要：
目的:研究亚麻籽油对链尿佐菌素(streptozocin,STZ)诱导的大鼠糖尿病肾病(diabetic nephropathy,DN)保护作用,并与鱼油对比功效。方法:采用一次性腹腔注射STZ的方法建立大鼠糖尿病肾病的模型,将实验大鼠分为阴性对照组、模型组、3个亚麻籽油剂量组(0.3、0.6、0.9 mL/100 g mb)、鱼油组(0.6 mL/100 g mb),研究亚麻籽油和鱼油对大鼠空腹血糖、糖耐量、糖化血清蛋白等糖代谢相关指标,尿量、尿蛋白、肌酐、尿素氮等肾功能指标,以及对细胞炎症因子和氧化应激的影响;并观察胰腺和肾脏的组织形态变化。结果:与模型组相比,亚麻籽油和鱼油均能显著性地降低STZ诱导的糖尿病肾病大鼠的空腹血糖值,改善糖耐量和糖化血清蛋白,降低尿量和尿蛋白,改善肾功能,降低机体的炎症反应,并增强抗氧化能力,显著性升高血清中葡萄糖转运蛋白4、胰岛素和肝脏中丙酮酸激酶、己糖激酶的表达(P<0.05或P<0.01)。亚麻籽油能够改善DN大鼠胰脏、肾脏组织结构损伤。结论:亚麻籽油和鱼油对STZ诱导的DN均有一定的保护作用。其作用机制可能与调节糖代谢、抗炎能力以及抗氧化有关。在调节糖代谢上鱼油的效果较好,而亚麻籽油对肾脏保护作用效果更好。
译  名：
Protective Effect of Flaxseed Oil on Diabetic Nephropathy Induced by Streptozocin in Rats
作  者：
NIU Jiahui;FU Mengqi;ZHOU Qian;WANG Yaxu;WU Mengying;ZHAO Wen;WANG Jie;Hebei Agricultural Product Processing Engineering Technology Center, College of Food Science and Technology,Hebei Agricultural University;
关键词：
flaxseed oil;;streptozotocin;;diabetic nephropathy;;protective effect
摘  要：
Objective: To explore the protective effect of flaxseed oil in comparison with fish oil on streptozotocin(STZ)-induced diabetic nephropathy(DN) in rats. Methods: An animal model of DN was established by a single intraperitoneal injection of STZ in rats. The experimental rats were divided into one negative control group, one model group, three flaxseed oil groups(0.3, 0.6, and 0.9 mL/100 g mb), and one fish oil group(0.6 mL/100 g mb). Glucose metabolism indexes including fasting blood glucose, glucose tolerance and glycosylated serum protein(GSP), renal function indexes including urine volume, urine protein, creatinine and urea nitrogen, as well as cytokines and oxidative stress status were determined in all the animals. Histological changes of pancreas and kidney tissues were observed. Results: Compared with the model group, flaxseed oil and fish oil could significantly reduce fasting blood glucose level, improve glucose tolerance and GSP, decrease urine volume and urine protein, improve renal function and reduce inflammatory reactions. Both of them could enhance antioxidant capacity and significantly increase the expression of glucose transporter-4, insulin, pyruvate kinase and hexokinase in liver(P < 0.05 or P < 0.01). Moreover, histopathological observation showed that flaxseed oil could alleviate pancreas and kidney injury in DN rats. Conclusion: Both flaxseed oil and fish oil have a protective effect on STZ-induced DN. The underlying mechanism may be related to the regulation of glucose metabolism, and the anti-inflammatory and antioxidant capacity. Comparatively, fish oil is more effective in regulating carbohydrate metabolism, while flaxseed oil has a better protective effect on the kidney.

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