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Position: Home > Articles > Maximum Dosage Test of Kangbingdu Oral Liquid in Mice Journal of Anhui Agricultural Sciences 2014 (23) 74+130

抗病毒口服液对小鼠的最大耐受量研究

作  者:
曹威;张文波;朱亮;韩旭;任超
单  位:
天津农学院动物科学与动物医学学院
关键词:
抗病毒口服液;急性毒性;最大给药量;病理组织学
摘  要:
[目的]通过最大给药量试验了解抗病毒口服液对小鼠的急性毒性。[方法]抗病毒口服液急性毒性试验中采用最大给药量,观察小鼠给药7 d内的临床症状,然后通过剖检及病理组织学观察研究抗病毒口服液的急性毒性。[结果]与对照组相比,试验组小鼠以最大给药量(人用剂量500倍)灌胃没有明显的异常反应,体重与对照组相比差异不显著,剖检和病理组织学观察无可见病变。[结论]抗病毒口服液对小鼠无急性毒性,可作为兽医临床用药安全使用。
译  名:
Maximum Dosage Test of Kangbingdu Oral Liquid in Mice
作  者:
CAO Wei;REN Chao;College of Animal Science and Veterinary Medicine,Tianjin Agricultural University;
关键词:
Kangbingdu oral liquid;;Acute toxicity;;Maximum dosage;;Histopathology
摘  要:
[Objective]To study the acute toxicity of Kangbingdu oral liquid in mice through maximum dosage test.[Method] The clinical symptoms were recorded for 7 days after the mice were given the maximum dosage of Kangbingdu oral liquid in acute toxicity test.Autopsy and histopathological observation were carried out to study the acute toxicity of Kangbingdu oral liquid in mice.[Result]The mice had not abnormal response and pathological changes in autopsy and histopathological observation compared to the control group in the maximum dosage(500 times of the clinical dosage in human).The weight was also insignificant difference compared to the control group.[Conclusion]Kangbingdu oral liquid did not show the acute toxicity,which is safe in veterinary clinical treatment.

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