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Position: Home > Articles > Synthesis of Prothioconazole via Continuous Flow Oxidation Modern Agrochemicals 2018 (5) 16-18+27

连续流氧化工艺合成丙硫菌唑

关键词:
丙硫菌唑;连续流;微反应器;氧化;工艺
摘  要:
丙硫菌唑是新型广谱三唑硫酮类杀菌剂,其合成过程中氧化条件苛刻,规模化生产存在很大挑战,为此开发了清洁、温和的连续流氧化工艺。在微通道反应器中,中间体2-(1-氯环丙烷-1-基)-1-(2-氯苯基)-2-羟基-3-(1,2,4-三唑烷-5-硫酮-1-基)-丙烷在氧化剂作用下,连续高效合成丙硫菌唑。在优化条件下,该中间体可以定量转化为丙硫菌唑。连续流氧化工艺条件温和,转化率高,适合工业化生产。
译  名:
Synthesis of Prothioconazole via Continuous Flow Oxidation
作  者:
Li Pei-zhu;Cheng Jie;Fan Jia-hui;Su Xian-bin;College of Chemical Engineering, Nanjing Tech University;
单  位:
Li Pei-zhu%Cheng Jie%Fan Jia-hui%Su Xian-bin%College of Chemical Engineering, Nanjing Tech University
关键词:
prothioconazole;;continuous flow;;micro-reactor;;oxidation;;technology
摘  要:
Prothioconazole is a new triazolinthione fungicide with broad spectrum bioactivities. A big challenge in the large scale preparation of prothioconazole is the oxidation condition. Thus a clean and mild continuous flow oxidation process was studied. The intermediate 1-(2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl)-1 H-1,2,4-triazole-5(4 H)-thione was oxidized in the presence of oxidant in micro-reactor to generate prothioconazole continuously. Prothioconazole could be synthesized efficiently under optimized condition. The continuous flow oxidation method featured with the advantages of mild reaction condition and high total yield, and it was suitable for industrial production.

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