Position: Home > Articles > Immunoenhancing Activity of Mactra chinensis Meat Extract in Mice
FOOD SCIENCE
2013,34
(17)
305-308
中国蛤蜊精对小鼠免疫活性观察
作 者：
史倩;王晓洁;张志伟;刘晓晨;梁建光;王守海;刘新生;曲彦清
单 位：
鲁东大学校医院;鲁东大学生命科学学院
关键词：
中国蛤蜊精;细胞免疫;体液免疫;非特异性免疫
摘 要：
目的:观察中国蛤蜊精(每100g中,含多糖19.01g、牛磺酸1.25g、胆碱0.65g)对小鼠免疫功能的影响。方法:用中国蛤蜊精按0.5、1.5、3.0g/(kg·d)的剂量对小鼠灌胃,连续10d,测定小鼠白细胞总数及分类计数、通过抗体凝集反应实验测定效价、测定抗体生成细胞水平、腹腔巨噬细胞吞噬功能、体质量变化及免疫器官质量,并对其结果进行统计分析。结果:与生理盐水组(对照组)相比,中国蛤蜊精各剂量组淋巴细胞相对数、抗体生成水平、抗体生成细胞水平、小鼠腹腔巨噬细胞吞噬功能和脾脏指数均显著升高(P<0.05)。结论:中国蛤蜊精有显著增强小鼠免疫功能的作用。
译 名：
Immunoenhancing Activity of Mactra chinensis Meat Extract in Mice
作 者：
SHI Qian;WANG Xiao-jie;ZHANG Zhi-wei;LIU Xiao-chen;LIANG Jian-guang;WANG Shou-hai;LIU Xin-sheng;QU Yan-qing;College of Life Science, Ludong University;College of Hospital, Ludong University;
关键词：
water extract from Mactra chinensis(EMC);;cellular immunity;;humoral immunity;;nonspecific immunity
摘 要：
Objective: To observe the immunoregulatory effect of Mactra chinensis meat extract(EMC, containing 19.01 g of polysaccharide, 1.25 g of taurine and 0.65 g of choline /100 g) in mice. Methods: Mice were orally administered with EMC at doses of 0.5, 1.5, 3.0 g/(kg · d) for 10 d. A series of immune function indices such as the total number and classification of white blood cells(WBC), the titer of antibody production in agglutination reaction and the quantity of plaque-forming cells(PFC), macrophage phagocytosis test, and the weight of body and immune organs were analyzed. Results: Compared with the control group, the relative number of lymphocytes, the activity of antibody production, the quantity of antibody-forming cells, the phagocytic function of mouse peritoneal macrophages and the index of spleen in all the treated groups were improved significantly( P <0.05). Conclusion: EMC enhances the immune activity of normal mice effectively.
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