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Position: Home > Articles > Research Progress on piRNA Formation and Function in Female Animals Chinese Journal of Animal and Veterinary Sciences 2017,48 (10) 1785-1795

piRNA的形成及其在雌性动物中生物学功能研究进展

作  者：
李春艳;任春环;刘秋月;胡文萍;王翔宇;曹晓涵;张子军;狄冉;储明星
单  位：
安徽农业大学动物科技学院
关键词：
piRNA;Piwi蛋白;表观遗传调控;雌性动物
摘  要：
piRNA是继siRNA和miRNA之后发现的一类新型非编码小RNA,其与Piwi蛋白协同作用参与piRNA通路,保护动物生殖细胞的遗传信息免受分子寄生虫如转座子的有害影响。近年来,人们对piRNA发生过程的相关蛋白及生物学作用做了研究,发现多种Piwi亚家族蛋白能与piRNA结合形成Piwi-piRNA复合体,通过表观遗传调控参与生殖细胞形成与发育、生殖干细胞分化、性别决定等生物学功能。本文主要围绕piRNA的形成及特点、Piwi-piRNA复合体发挥生物学作用的方式、piRNA在雌性动物中的生物学功能这3个方面对近期的研究进展进行综述,为深入探究piRNA调控雌性动物繁殖机制提供参考。
译  名：
Research Progress on piRNA Formation and Function in Female Animals
作  者：
LI Chun-yan;REN Chun-huan;LIU Qiu-yue;HU Wen-ping;WANG Xiang-yu;CAO Xiao-han;ZHANG Zi-jun;DI Ran;CHU Ming-xing;Key Laboratory of Animal Genetics,Breeding and Reproduction of Ministry of Agriculture,Institute of Animal Science,Chinese Academy of Agricultural Sciences;College of Animal Science and Technology,Anhui Agricultural University;
单  位：
Key Laboratory of Animal Genetics,Breeding and Reproduction of Ministry of Agriculture,Institute of Animal Science,Chinese Academy of Agricultural Sciences%College of Animal Science and Technology,Anhui Agricultural University
关键词：
piRNA;;Piwi protein;;epigenetic regulation;;female animals
摘  要：
Following the discovery of siRNA and miRNA,a new class of small noncoding RNA,called piRNA,was found.piRNA can interact with Piwi subfamily proteins and they involve in piRNA pathways,which can protect genetic information of animal germ cells from the harmful effects of molecular parasites such as transposon.In recent years,piRNA biogenesis-related proteins and their biological effects were studied.It was found that a variety of Piwi subfamily proteins could bind to piRNA to form Piwi-piRNA complex.These complexes were involved in germ cells formation and development,germline stem cells differentiation,sex determination and other biological functions through the way of epigenetic regulation.In the present paper,we reviewed the research progress on the biogenesis and characteristics of piRNA,the ways of Piwi-piRNA comple-xes playing the biological roles and biological functions of piRNA in female animals,which will provide a reference for further research on regulatory mechanism of piRNA in female animal reproduction.

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