当前位置: 首页 > 文章 > 阿莫西林钠-酒石酸泰乐菌素复方药物治疗猪链球菌病的研究 东北农业大学学报 2009,40 (11) 97-100
Position: Home > Articles > Study on the amoxillin-tylosin tartrate compound against Streptococcos suis in mice Journal of Northeast Agricultural University 2009,40 (11) 97-100

阿莫西林钠-酒石酸泰乐菌素复方药物治疗猪链球菌病的研究

作  者:
王敏;徐刚;刘洋;陈俭清;李艳华
单  位:
东北农业大学动物医学学院
关键词:
阿莫西林钠;阿莫西林钠-酒石酸泰乐菌素复方药物;猪链球菌病;昆明鼠;药效学
摘  要:
为研究阿莫西林钠-酒石酸泰复方药物乐菌素治疗猪链球菌病的药效学,选用60只15g左右的昆明鼠,以多重耐药的临床分离猪链球菌为病原,以腹腔注射为感染途径,对猪链球菌的病理模型进行了复制,按照Reed-Munch法计算LD50为9.61×108cfu·mL-1。在此基础上,选用80只昆明鼠,接种LD50菌液,分别口服阿莫西林钠,酒石酸泰乐菌素及阿莫西林钠-酒石酸泰乐菌素复方药物。结果表明,阿莫西林钠-酒石酸泰乐菌素复方药物组的作用效果明显优于单药组,小鼠存活率为80%,阿莫西林钠组的小鼠存活率为70%,酒石酸泰乐菌素组为60%。
译  名:
Study on the amoxillin-tylosin tartrate compound against Streptococcos suis in mice
作  者:
WANG Min,XU Gang,LIU Yang,CHEN Jianqing,LI Yanhua(College of Veterinary Sciences,Northeast Agricultural University,Harbin 150030,China)
关键词:
Amoxicillin;amoxillin-tylosin tartrate compound;Streptococcus suis;Kunming mice;pharmacodynamics
摘  要:
To evaluate the pharmacodynamics of amoxillin-tylosintartrate against Streptococcus suis in Kunming mice.Kunming mice were infected by intraperitoneal injection with 1 mL of Streptococcus suis isolated.LD50 was 9.61×108 cfu·mL-1 by Reed-Muench method.The mice were given by amoxillin,tylosin tartrate and amoxillin-tylosin tartrate compound respectively.The results showed that amoxillin-tylosin-tartrate was better than amoxilin,the survival rate was 80%.

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