Xinyi Li;Mengya Wang;Shimin Liu;Xiao Chen;Yu Qiao;Xiaojun Yang;Junhu Yao;Shengru W

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China; Department of Medicine, Karolinska Institutet, Solna, Stockholm 17165, Sweden;College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, Chin;Institute of Agriculture, University of Western Australia, Crawley, WA 6009, Australia; Department of Animal Engineering, Yangling Vocational and Technical College, Yangling, Shaanxi 712100, China

Antibiotic replacement;Growth;Immune;Nutrition;Transgenerational epigeneti

The use of antibiotics in animal feeding has been banned in many countries because of increasing concerns about the development of bacterial resistance to antibiotics and potential issues on food safety. Searching for antibiotic substitutes is essential. Applying transgenerational epigenetic technology to animal production could be an alternative. Some environmental changes can be transferred to memory-like responses in the offspring through epigenetic mechanisms without changing the DNA sequence. In this paper, we reviewed those nutrients and non-nutritional additives that have transgenerational epigenetic effects, including some amino acids, vitamins, and polysaccharides. The paternal transgenerational nutritional epigenetic regulation was particularly focused on mechanism of the substantial contribution of male stud animals to the animal industries. We illustrated the effects of paternal transgenerational epigenetics on the metabolism and immunity in farming animals and proposed strategies to modulate male breeding livestock or poultry.