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Position: Home > Articles > Effect of Lincomycin Hydrochloride on the Intestinal Flora of Mice Journal of Anhui Agricultural Sciences 2013,41 (9) 3913-3914,4136

盐酸林可霉素对小鼠肠道茵群的影响

作  者:
谢莉敏;李丹;程秀芳;刘虹;黄启亮;王丛丛;谷巍
单  位:
山东宝来利来生物工程股份有限公司
关键词:
盐酸林可霉素;肠道茵群;影响
摘  要:
[目的]研究不同剂量盐酸林可霉素对小鼠肠道菌群的影响,为正确使用盐酸林可霉素提供参考资料.[方法]分别以80和120mg/d剂量的盐酸林可霉素,连续灌胃小鼠5和7d,分别于停药后第1、3,7、10和15天检测小鼠直肠球菌、杆菌、乳酸茵及双歧杆菌数;[结果]各盐酸林可霉素给药组皆可造成小鼠肠道茵群失调.[结论]低剂量灌胃盐酸林可霉素可用于制备小鼠肠道茵群失调模型,高剂量给药可对小鼠机体造成损害.
译  名:
Effect of Lincomycin Hydrochloride on the Intestinal Flora of Mice
关键词:
Lincomycin hydroehloride% Intestinal flora% Effect
摘  要:
[ Objective ] Through observing the effect of different doses of lincomycin hydrochloride on the intestinal flora of mice, so as to pro- vide the reference data for the correct use of lincomycin hydrochlorid on the study work. [ Method] The mice in study groups were continuous lavaged 80 and 120 mg/d doses of lincomycin hydrochloride 5 and 7 days, then test the number of bacillus, enterococci, laetobacillus and bifidobactefium in rectal of mice after stop giving lincomycin hydrochlorid 1, 3, 7, 10,15 days. [ Result] The lincomycin hydrochlofide treat- ment group all can cause mice intestinal dysbacteriosis. [ Conclusion] Giving mice 80 mg/d doses lincomycin hydrochloride can be used in the preparation of mice intestinal dysbacteriosis model and giving 120 mg/d doses can damage the mice.

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