Position: Home > Articles > Experimental Study on Defecating Function of Codonopsis Pilosula Water Extract
Food and Nutrition in China
2018
(11)
73-77
党参水提物的通便作用研究
作 者：
陈亮;阚君陶;田峰;韩强;李敏杰;瞿晶菁;樊柏林;杜军
单 位：
应用毒理湖北省重点实验室;安利(中国)研发中心有限公司;湖北省疾病预防与控制研究中心
关键词：
党参水提物;小肠推进;排便;5-HT;VIP
摘 要：
目的:研究党参水提物对便秘小鼠小肠推进和排便的影响。方法:采用复方地芬诺酯造成小鼠便秘模型,给予高、中、低3个剂量组(3 333、1 667、833mg/kg·BW)的党参水提物进行干预,观测其对小肠推进的作用,并采用酶联免疫方法对便秘小鼠结肠组织中五羟色胺(5-HT)和血管活性肽(VIP)水平进行测定,探讨其可能的影响机制;采用复方地芬诺酯灌胃造成便秘小鼠模型,观察党参水提物对小鼠排便的影响。结果:小肠推进实验结果显示,3个剂量组的党参水提物对小肠推进均有明显的促进作用:5-HT和VIP指标测定结果显示,高剂量和低剂量党参水提物能够显著增加便秘小鼠肠道内5-HT水平,减少VIP的释放;小鼠排便实验结果显示,高剂量党参水提物对便秘小鼠的排便有明显的改善,能缩短首粒排黑便时间、增加排黑便重量,低剂量组能明显增加排黑便重量。结论:党参水提物具有潜在的通便作用。
译 名：
Experimental Study on Defecating Function of Codonopsis Pilosula Water Extract
作 者：
CHEN Liang;KAN Jun-tao;TIAN Feng;HAN Qiang;LI Min-jie;QU Jing-jing;FAN Bo-lin;DU Jun;Amway (China) R&D Center;Key Lab of Applied Toxicology of Hubei Province;Center for Disease Prevention and Control of Hubei Province;
单 位：
China
关键词：
Codonopsis Pilosula water extract;;intestinal propulsion;;defecation;;5-HT;;VIP
摘 要：
【Objective】 To investigate the intestinal propulsion and defecation functions of Codonopsis Pilosula water extracts. 【Method】 Effects of intestinal propulsion of Codonopsis Pilosula water extracts had been studied in mice model using diphenoxylate as model drug. 5-hydroxytryptamine( 5-HT) and vasoactive intestinal polypeptide( VIP) level in the colonic tissue of constipated mice had been detected by enzyme-linked immunoassay method. Defecation effects of Codonopsis Pilosula water extracts had been studied in mice model also using diphenoxylate as model drug. 【【Result】】 It was found that Codonopsis Pilosula water extracts,high dose( 3 333 mg/kg·BW),medium dose( 1 667 mg/kg·BW) and low dose( 833 mg/kg·BW) significantly improved the intestinal propulsion. Meanwhile,the 5-HT level in intestinal tract of constipated mice significantly increased by the influences of high and low dose of Codonopsis Pilosula water extracts,and an opposite influence on VIP level was observed. In defecating experiment,it was found high dose of Codonopsis Pilosula water extracts could significantly decrease the time of first black fecal grain and increase the total fecal weight,and low dose group could increase the total fecal weight. 【Conclusion】 Codonopsis Pilosula water extract may have the potential function of defecation improvement.
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