当前位置: 首页 > 文章 > 星点设计-效应面法优化葛根黄酮固体脂质纳米粒处方 特产研究 2015,43 (2) 9-11+22
Position: Home > Articles > Optimization of the Formula for Puerarin Flavonoids Solid Lipid Nanoparticle by Central Design- Response Surface Method Special Wild Economic Animal and Plant Research 2015,43 (2) 9-11+22

星点设计-效应面法优化葛根黄酮固体脂质纳米粒处方

作  者:
张广远;孙士淋;刘昕;樊红波;王玉;管清香
单  位:
吉林大学药学院
关键词:
葛根黄酮;星点设计;固体脂质纳米粒
摘  要:
采用星点设计-效应面法优化葛根黄酮纳米粒处方。以脂质硬脂酸、乳化剂泊洛沙姆188及大豆卵磷脂用量为因变量,以包封率为应变量,溶剂扩散法制备葛根黄酮固体脂质纳米粒。结果表明,二项拟合方程优于多元线性回归方程,脂质硬脂酸最佳范围为0.50g~0.65g,乳化剂泊洛沙姆188最佳范围为0.125g~0.140g,大豆卵磷脂最佳范围为0.25g~0.45g。结果证实,此范围内制得纳米粒包封率与预测值较为接近,拟合方程可较好预测实验结果。
译  名:
Optimization of the Formula for Puerarin Flavonoids Solid Lipid Nanoparticle by Central Design- Response Surface Method
作  者:
ZHANG Guang-yuan;SUN Shi-lin;LIU Xin;FAN Hong-bo;WANG Yu;GUAN Qing-xiang;School of Pharmacy,Jilin University;
关键词:
puerariaflavonoids;;central composite design;;solid lipid nanoparticle
摘  要:
Central design- response surface method was employed to optimize the formula of puerarin flavonoids solid lipid nanoparticle( PF- SLN). Dosages of stearic acid,poloxamer 188 and soybean lecithin were chosen as independent variables,entrapment efficiency was selected as dependent variable solvent,injection method was used to prepare PF- SLN. The results showed that binomial fitting equations of indexes were all superior to that of multi- linear regression equations. The optimal dosage of stearic acid,poloxamer 188 and soybean lecithin were 0. 50g- 0. 65 g,0. 125g- 0. 14 g,0. 25g- 0. 45 g respectivel. The predictive values of entrapment efficiency were in conformity with the experimental values well.

相似文章

计量
文章访问数: 16
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊