Position: Home > Articles > CALR:A New Biomarker for Chronic Myeloproliferative Neoplasms(CMPN)
Journal of Yangtze University(Natural Science Edition)Agricultural Science Volumn
2015
(30)
83-86+5
CALR基因:慢性骨髓增殖性肿瘤(CMPN)新分子标记物
作 者：
周靖;黄知平
单 位：
长江大学荆州临床医学院荆州市中心医院血液内科
关键词：
慢性骨髓增殖性肿瘤;钙网蛋白基因(CALR)突变;分子标记物
摘 要：
慢性骨髓增殖性肿瘤(CMPN)是骨髓中一系或多系髓系细胞增殖的克隆性造血干细胞疾病。近年来,多个分子标志物如JAK2、MPL基因突变等相继被发现,但仍有30%~45%的携有野生型JAK2/MPL的原发性血小板增多症(ET)或原发性骨髓纤维化(PMF)患者缺乏特异性分子标记物,诊断存在困难。近期新发现的钙网蛋白基因(CALR)突变将能填补这一空白,有望成为诊断骨髓增殖性肿瘤又一种新的分子标记物,对于理解CMPN的分子发病机制具有重要意义,对这类疾病进行诊断和治疗具有重要意义。
译 名：
CALR:A New Biomarker for Chronic Myeloproliferative Neoplasms(CMPN)
作 者：
Zhou Jing;Huang Zhiping;Department of Hematology,the Central Hospital of Jingzhou;
关键词：
chronic myeloproliferative neoplasms;;calreticulin mutations;;biomarker
摘 要：
Chronic myeloproliferative neoplasms(CMPN)are clonal hematopoietic stem cell diseases characterized by proliferation of one or more myeloid lineages in the bone marrow.In recent years,several molecular markers have been found,such as JAK2 and MPL mutations.However,diagnosis remains difficult for approximately 30% to 45% ET or PMF patients with JAK2 or MPL who need specific molecular markers.As reported recently,the discovery of calreticulin(CALR)mutations fills the molecular diagnostic gap and may be a new biomarker for CMPN.The discovery is significant for better understanding the pathogenesis of CMPN and is helpful for the both diagnosis and therapy.
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