单 位：
昆明理工大学生命科学与技术学院;云南大学中草药生物资源研究所云百草实验室;昆明市虫草生物资源开发利用工程技术研究中心
摘 要：
目的:研究兰坪虫草对小鼠运动的抗疲劳效果。方法:小鼠随机分为5个实验组,分别为兰坪虫草低剂量组(450 mg/(kg·d))、中剂量组(900 mg/(kg·d))、高剂量组(1 800 mg/(kg·d))以及空白组(蒸馏水)、阳性对照组(西洋参600 mg/(kg·d)),连续灌胃30 d,研究兰坪虫草对小鼠负重游泳时间、血乳酸、血清尿素氮、肝糖原、抗氧化酶、血液相关参数等疲劳指标的影响。结果:各剂量组兰坪虫草均能显著延长小鼠负重游泳时间(P<0.05);中、高剂量组可以显著降低小鼠运动后血清尿素氮浓度(P<0.05);高剂量组和阳性对照组能显著提高小鼠体内肝糖原的储备量(P<0.05);同时,兰坪虫草能提高血液血红蛋白和血糖浓度,明显增加抗氧化酶的活力,降低丙二醛水平。结论:研究证明兰坪虫草具有缓解小鼠运动疲劳的作用。
译 名：
Sport Fatigue-Alleviating Effect of Ophiocordyceps lanpingensis
作 者：
KONG Na;YU Hong;ZHANG Yanyan;GE Feng;Faculty of Life Science and Technology, Kunming University of Science and Technology;Yunnan Herbal Laboratory, Institute of Herb Biotic Resources, Yunnan University;The Research Center of Cordyceps Development and Utilization of Kunming;
关键词：
Ophiocordyceps lanpingensis;;anti-fatigue;;anti-oxidant;;Ophiocordyceps lanpingensis
摘 要：
Objective: To investigate the anti-fatigue effect of Ophiocordyceps lanpingensis(OL) in mice. Methods: Mice were randomly divided into five groups: negative control(orally administered with distilled water), positive control(administered with 600 mg/(kg·d m_b) of American ginseng) and OL low-, medium-and high-dose(gavaged with OL powder at doses of 450, 900, and 1 800 mg/(kg·d m_b), respectively) groups. After administration for 30 days, the weight-loading swimming time as well as blood lactic acid, blood urea nitrogen(BUN), glycogen(LG) and antioxidant enzyme activities and other fatigue-related blood parameters in the mice were determined. Results: Ophiocordyceps lanpingensis could increase the weight-loading swimming time of mice at all doses(P < 0.05); the mice from the middle-and high-dose group showed significantly reduced levels of BUN after exercise(P < 0.05); the mice from the high-dose group and the positive control group could significantly improve LG level(P < 0.05). Meanwhile, Ophiocordyceps lanpingensis improved blood hemoglobin and blood sugar levels, increased the activity of antioxidant enzymes, and reduced blood malondialdehyde content. Conclusion: Ophiocordyceps lanpingensis has an anti-fatigue effect in mice.
