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当前位置: 首页 > 文章 > 枸骨的化学成分和药理活性研究进展 安徽农业科学 2011,39 (27) 16560-16562
Position: Home > Articles > Research Advances of the Chemical Constituents and Pharmacological Activities of Ilex cornuta Lindl.et Paxt Journal of Anhui Agricultural Sciences 2011,39 (27) 16560-16562

枸骨的化学成分和药理活性研究进展

作  者：
左文健;梅文莉;曾艳波;王辉;戴好富
单  位：
中国热带农业科学院热带生物技术研究所
关键词：
枸骨;化学成分;药理作用
摘  要：
[目的]概述从枸骨(Ilex cornuta Lindl.et Paxt.)中分离得到的化学成分及其药理作用研究进展,并探讨了今后研究的主要方向。[方法]搜集整理现有的有关枸骨化学成分和药理作用的研究结果。[结果]文献报道,从枸骨中共分离得到40个化合物,主要为三萜皂苷及其苷元、黄酮及其苷类、多酚类及其衍生物、脂肪酸类和其他类(包括链状倍半萜tanacetene、胡萝卜苷和苦丁茶糖脂素甲、乙等),其中,三萜皂苷及其苷元18个,黄酮及其苷类5个,多酚类及衍生物5个,脂肪酸类7个,其他类6个。枸骨提取物的药理活性主要有降血脂、抗菌和抗生育等作用。其中,单体化合物熊果酸具有镇静、消炎、抗菌、抗糖尿病、抗溃疡、降低血糖,提高免疫作用、抗致癌、抗促癌、诱导F9畸胎瘤细胞分化和抗血管生成作用等多种生物效应;槲皮素和金丝桃苷具有较强的镇痛、增强脑组织血流量和抗脑缺血性损伤等活性;枸骨苷4对脑垂体后叶素诱发的大鼠心肌缺血有一定的保护作用,可显著降低心肌收缩力;腺苷对冠脉血流有增加作用,3,4-二咖啡酰鸡纳酸对前列腺环素(PGI2)的释放有较显著促进作用。[结论]该研究可以为更好地开发和利用枸骨资源提供参考。
译  名：
Research Advances of the Chemical Constituents and Pharmacological Activities of Ilex cornuta Lindl.et Paxt
作  者：
ZUO Wen-jian et al(Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou,Hainan 571101)
关键词：
Ilex cornuta Lindl.et Paxt.;Chemical constituents;Pharmacological activity
摘  要：
[Objective] To review the research advances of the chemical constituents and pharmacological activity of Ilex cornuta Lindlet.Paxt,and study its future research orientation.[Method] The existing researches on the chemical consitutent and pharmacological activity of Ilex cornuta Lindl.et Paxt.were collected.[Result] 40 compounds have been seperated from Ilex cornuta Lindl.et Paxt.,including 18 triterpenoid saponins and its aglycon,5 flavone and its glycoside,5 polyphenols and its derivatives,7 fatty acids and 6 others(including tanacetene,daucosterol,cornutaside A and B).Ilex cornuta Lindl.et Paxt.extracts had the hypolipidemic,antimicrobial and antifertility effect.The monomeric compound ursolic acid had the sedative,anti-imflammatory,antimicrobial,antibiabetic,antiulcer and hypolipidemic efficacy,and improved the immune function,the anti-carcinogeneic and anti-angiogenic effect and the induced differentiation of F9 teratoma cells;quercetin and hyperin had strong sedative and anti-cerebral ischemic injury effect,and could enhance cerebral blood flow;cornuta glycosides could protect the myocardial ischemia of rats induced by pituitrin and significantly reduce myocardial contractility;adenosine increased coronary blood flow,3,4-Dicaffeoyl-quinic acid significantly improved the release of PGI2.[Conclusion] The study provided references for better developing and utilizing the Ilex cornuta Lindl.et Paxt.resources.

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