Yang Qun;Kai Zhan

effervescent granules;pericarpium granati;particle size;70% ethanol;solid-liquid ratio;the preparation proces

[Objective] To explore the preparation process of PERICARPIUM GRANATI effervescent granules.[Method] Taking the content of total flavonoids as an index,the ultrasonic extraction process of PERICARPIUM GRANATI was optimized by means of L9(34) orthogonal test with ethanol concentration,extraction times,solid-liquid ratio,extraction temperature as experimental factors.Refined extract and adjuvants were mixed to prepare effervescent granules.The angle of repose,moisture content,dissolubility,and particle size of effervescent particles were detected.[Result] The optimum ultrasonic extracting conditions of PERICARPIUM GRANATI were as follows: solvent of 70% ethanol,extraction times of 1,extraction time of 30 min and solid-liquid ratio of 1∶ 25 g/ml.The formula of effervescent granules was established as follows: PERICARPIUM GRANATI thick paste 10 g,lactose 74 g,cane sugar 4 g,citric acid 3 g,sodium bicarbonate 25 g,polyethylene glycol 6000 14 g,70% ethanol.The angle of repose of effervescent granules was 29.6o and showed good liquidity.The moisture content,the particle size and the dissolubility of granules conformed to the pharmacopoeia stipulation.[Conclusion] The preparation process is simple,and the quality is stable and controllable,so it is fit for industrialized production of PERICARPIUM GRANATI effervescent granules.