Cheng-Zhe Jiang;Ilhyun Han;Se‐Young Choun

Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Kore;Department of Veterinary Medicine, College of Agriculture, Yanbian University, Yanji 133000, Jilin, China.;Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea

cisplatin;decursin;cisplatin-induced nephrotoxicity;nephrotoxicity;creatinine;bu

Tisplatin is one of the valuable icancer agents against several types of neoplasm. However, nephrotoxicity is the major adverse effect representing in cisplatin therapy. In this study, the animal tests detecting protective effects of a natural compound, Decursin, on cisplatin-induced nephrotoxicity were examined by using in vivo model. Pretreatment Decursin 10, 20 and 40 mg · kg−1 at 48, 24 and 6 h, and administration of a single dose of Cisplatin 5.2 mg · kg−1. Nephrotoxicity was evaluated by serum BUN and creatinine examination. There was significant difference in body weights, serum BUN and creatinine levels of the normal group. Based on the new understanding of the protective mechanisms of cisplatin-induced nephrotocivity, new strategies can be developed to prevent renal injury or to enhance recovery after cisplatin treatment.