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Composition and antioxidant activity of Paeonia lactiflora petal flavonoid extract and underlying mechanisms of the protective effect on H2O2-induced oxidative damage in BRL3A cells

作者：

Lei Liu;Yingdan Yuan;Jiajia Zuo;Jun Ta

单位：

College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009, China;College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu 225009, Chin; College of Horticulture, Xinyang Agriculture and Forestry University, Xinyang, Henan 464000, China;College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu 225009, China

关键词：

Antioxidant activity;Flavonoid;Herbaceous peony petal;Oxidative stress;Solid-phase extractio

摘要：

Flavonoids have attracted considerable attention due to their health benefits. This study aimed to investigate the flavonoid profiles and antioxidant activity of Paeonia lactiflora petal flavonoid extract (PPF). The UHPLC-ESI-Q-Exactive HF MS/MS method was established for characterization, and 21 predominant flavonoid compounds were tentatively identified in PPF. Among them, isoscutellarein-7-(6'-acetylallosyl-(1->2)-glucoside) and scutellarin methylester were discovered in PPF for the first time. Pretreatment with PPF significantly reduced H2O2-induced cell damage, ROS accumulation, and malondialdehyde content and increased the activity of SOD, CAT, and GSH-Px in buffalo rat liver 3A (BRL3A) cells. Moreover, the expression of nuclear Factor E2-related factor (Nrf2) was upregulated by PPF, whose expression trend was consistent with that of heme oxygenase-1 (HO-1), glutamate-cysteine ligase catalytic subunit (GCLC), and NAD(P)H quinone oxidoreductase-1 (NQO1). These findings suggested that herbaceous peony flavonoids can be used as a natural bioactive agent to prevent oxidative stress.

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Composition and antioxidant activity of Paeonia lactiflora petal flavonoid extract and underlying mechanisms of the protective effect on H2O2-induced oxidative damage in BRL3A cells

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