Position: Home > Articles > Preparation and Content Determination of Compound Scrophulariae Troches
Journal of Anhui Agricultural Sciences
2011,39
(32)
19795-19797
复方玄参口含片的制备及含量测定
作 者：
Feng Suomin;Yun Wang;Gao WenQing;Qing LiYuan;Xue PengChao;Wenli Su
单 位：
,WANG Yun2,GAO Wen-qing1,QING Li-yuan1,XUE Peng-chao1,SUN Wen-ji3
关键词：
troches;scrophulariae;compound;prescription;main;preparatio
摘 要：
[目的]制备复方玄参口含片并测定其主要有效成分的含量。[方法]以玄参地上部分提取物为主药,采用湿法制粒压片法,以口含片外观、口感和崩解时限等因素为指标,确定口含片的制备工艺路线,并筛选出最佳处方;以哈巴俄苷为指标,采用高效液相色谱法建立口含片的质量控制标准。[结果]最佳处方组成为玄参地上提取物(6.7%)、杜仲叶提取物(4%)、甘露醇与糖粉混合物(36.7%)(1∶1,V/V)、薄荷脑(0.95%)、硬脂酸镁(0.24%)。[结论]按照筛选的处方和研究的制备工艺,配制出了符合要求的口含片,并测定了其主要成分的含量。
译 名：
Preparation and Content Determination of Compound Scrophulariae Troches
作 者：
FENG Suo-min et al(Department of Pharmacy,Xi′an Medical University,Xi′an,Shaanxi 710021)
关键词：
Extract from the aerial parts of S.ningpoensis;E.ulmoides leaf extract;Troches;HPLC
摘 要：
[Objective] To prepare compound scrophulariae troches and determine the content of its main active ingredients.[Method] Taking the taste,appearance characteristics and disintegrating time as index,the prescription and preparation process of troches with the extracts from the aerial parts of Scrophularia ningpoensis Hemsl.as primary drug were confirmed through wet granulation tabletting method.Using the harpagoside as an index,HPLC method was adopted to establish a quality control standard for compound scrophulariae troches.[Result] The optimum prescription composed of 6.7% extracts from the aerial parts of S.ningpoensis,4% E.ulmoides leaf extract,36.7% mixture of mannitol and sugar(V/V,1∶ 1),0.95% menthol crystal and 0.24% magnesium stearate.[Conclusion] In accordance with the selection of prescription and preparation,troches that conformed to the requirements were prepared,and the content of its main active ingredients were determined.
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