Position: Home > Articles > APPLICATION OF SUGAR AMINO ACIDS IN DRUG DESIGN AND SYNTHESIS
Transactions of Oceanology and Limnology
2007
(1)
105-111
氨基糖酸在药物分子设计与合成中的应用
作 者：
马瑞;万升标;江涛
单 位：
中国海洋大学医药学院教育部海洋药物重点实验室
关键词：
氨基糖酸;药物分子设计;多肽模拟物;组合化学;人工受体
摘 要：
用非天然的分子实体模拟天然活性分子以提高药物的活性和稳定性.是药物化学中的一个研究热点。氨基糖酸综合了糖和氨基酸结构特征和化学反应特性.是一类新型非天然的多肽模拟物构建模块,广泛的应用在多肽模拟学、组合化学和人工受体分子的构建中。本文综述了近年来氨基糖酸在药物分子设计与合成中的应用进展。
译 名：
APPLICATION OF SUGAR AMINO ACIDS IN DRUG DESIGN AND SYNTHESIS
作 者：
MA Rui WAN Shengbiao JIANG Tao*(College of Medicine and Pharmaceutics,Key Laboratory of Marine Drugs,Ministry of Education,Ocean University of China,Qingdao 266003)
关键词：
sugar amino acid;;drug Design;;peptidomimetics;;combinatorial chemistry;;artificial receptor
摘 要：
It is one of research interests in medicinal chemistry to mimic natural active mole- cules using unnatural molecular entities for higher activity and stability of drugs.Sugar ami- no acids combine the structural and chemical properties of sugar and amino acid,which are a novel class of peptidomimetics building blocks and used widely in peptidomimetics,combina- torial chemistry and build of artificial receptors.Current uses of sugar amino acids in drug design and synthesis are reviewed in this paper.
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