Position: Home > Articles > Review of advances in trimeric autotransporter adhesins
South China Fisheries Science
2012,08
(4)
72-77
三聚体自转运粘附素研究进展
作 者：
刘金叶;冯娟;徐力文;苏友禄;郭志勋
单 位：
中国水产科学研究院南海水产研究所
关键词：
三聚体自转运蛋白;粘附素;革兰阴性菌
摘 要：
粘附是病原菌感染宿主的第一步,而粘附素在细菌的粘附过程中起着重要的作用,是病原菌一个重要毒力因子。随着对病原菌致病机理研究的不断深入,人们在革兰阴性菌中发现了一类新的粘附素——三聚体自转运粘附素(trimeric autotransporter adhesions,TAAs)。这类粘附素广泛存在于变形菌门,是一类多功能的蛋白,经由细菌的Ⅴ型分泌系统分泌到菌体表面。被分泌到菌体表面的TAAs在大小和氨基序列上存在高度差异,但是它们在结构上却存在惊人的相似,即构成了一个头部-颈部-锚定区这样三聚化的类似于"棒棒糖"式的表面结构。文章就其结构、分泌机制和各区域功能进行了描述,以期为进一步的深入研究提供参考。
译 名：
Review of advances in trimeric autotransporter adhesins
作 者：
LIU Jinye1,2,FENG Juan1,XU Liwen1,SU Youlu1,GUO Zhixun1(1.Key Lab.of South China Sea Fishery Resources Exploitation & Utilization,Ministry of Agriculture;South China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou 510300,China; 2.Shanghai Ocean University,Shanghai 201306,China)
关键词：
trimeric autotransporter;adhesin;Gram-negative bacteria
摘 要：
Adhesion of bacteria to cell surfaces is the first step in infection,in which adhesin plays an important role and is a vital virulence factor for pathogens.A new kind of adhesins,trimetric autotransporter adhesins(TAAs) which are derived from Gram-negative bacteria,is found.TAAs are multifunctional proteins widely existing in Proteobacteria,secreted on cell surface by Ⅴ-type bacterial secretion system.TAAs have striking differences in size and amino sequence,but are surprisingly similar in molecular structure;they both have a trimetric surface structure with a head-stalk-anchor architecture which is like a "lollipop".The review describes the structure,secretion mechanisms and regional functions of TAAs to provide references for further study.
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