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Position: Home > Articles > Research Progress on Cellular Receptors of Porcine Reproductive and Respiratory Syndrome Virus China Animal Husbandry & Veterinary Medicine 2013 (7) 77-81

猪繁殖与呼吸综合征病毒细胞受体研究进展

作  者:
李红;周恩民;易建中
单  位:
上海市农业科学院畜牧兽医研究所;西北农林科技大学动物医学院
关键词:
猪繁殖与呼吸综合征病毒;受体;硫酸乙酰肝素;唾液酸黏附素;波形蛋白;CD163;非肌肉肌动蛋白ⅡA
摘  要:
猪繁殖与呼吸综合征病毒(porcine reproductive and respiratory syndrome virus,PRRSV)主要是通过与宿主细胞表面的特异性受体结合,利用细胞的内吞作用而感染易感细胞。作者对猪繁殖与呼吸综合征病毒相关受体的研究进行了综述,迄今已报道了5种独立的但功能相关的受体:硫酸乙酰肝素、唾液酸黏附素、波形蛋白、CD163和非肌肉肌动蛋白ⅡA。对受体的功能特性进行研究,将为PRRSV的感染机理和病毒性疾病的预防和治疗具有重要的意义。
译  名:
Research Progress on Cellular Receptors of Porcine Reproductive and Respiratory Syndrome Virus
作  者:
LI Hong1,ZHOU En-min2,YI Jian-zhong1(1.Animal Husbandry and Veterinary Research Institute,Shanghai Academy of Agricultural Sciences,Minhang 201106,China; 2.College of Veterinary Medicine,Northwest Agricultural and Forestry University,Yangling 712100,China)
关键词:
porcine reproductive and respiratory syndrome virus;receptor;sialoadhesin;heparin sulfate;vimentin;CD163;non-muscle myosinⅡA
摘  要:
Porcine reproductive and respiratory syndrome virus(PRRSV) enters the host cells via a mechanism of receptor-mediated endocytosis.The entry mechanism is mediated by attachment to one or more cellular receptors and/or coreceptor on the cell surface and internalization.This article mainly describes several receptors for PRRSV.As far,it is reported five receptors of PRRSV which are independent and associated,heparin sulphate(HS),sialoadhesin(Sn),vimentin,CD163 and non-muscle myosinⅡA.It plays a significant role for the mechanism of PRRSV infection or disease prevention and treatment by studying the function of cellular receptors of PRRSV.

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