关键词：
嘧苯胺磺隆;水分散粒剂;配方筛选;湿法制粒
摘 要：
[目的]探讨嘧苯胺磺隆水分散粒剂的制备方法。[方法]研究采用湿法挤压制粒法制备嘧苯胺磺隆水分散粒剂的配方组成。[结果]嘧苯胺磺隆水分散粒剂的配方组成为:嘧苯胺磺隆原药60%,润湿剂为十二烷基硫酸钠K12(用量为2%),分散剂为亚甲基二萘磺酸钠NNO(用量为4%),崩解剂为羧甲基淀粉钠CMS-Na(用量为5%),填充剂为膨润土(补足100%),粘合剂为10%的淀粉浆。制备工艺为:将配方量的除粘合剂之外的其他组分用槽型混合机混合均匀,加入粘合剂制软材,用摇摆式颗粒机制粒,经干燥、筛分后得到最终产品。制得产品经热贮稳定性试验,各项质量指标均符合国家有关水分散粒剂的规定。[结论]试验结果为嘧苯胺磺隆的进一步推广应用提供了理论依据。
译 名：
Study on the Recipe of Orthosulfamuron WDG
作 者：
WEI Yu-mei;WANG Zheng-ye;Jiangsu Provincial Xuzhou Pharmaceutical Vocational College;
关键词：
Orthosulfamuron;;Waterdispersible granule;;Prescription screening;;Wet-granulation
摘 要：
[Objective] The aim was to explore the preparation of orthosulfamuron WDG. [Method] the recipe of orthosulfamuron WDG was studied by using wet-granulation technology. [Result] The recipe of orthosulfamuron WDG was as followed: 60% orthosulfamuron,2% wetting agent K12,4% dispersant NNO,5% disintegrant CMS-Na,replenishing stuffing used bentonite clay to 100% and adhesive with 10%starch. The technological process included thoroughly blended recipe except adhesive using tank model mixing-machine,made humid soft materials with adhesive,made grands by using swing graulator. The ultimate products were obtained after being dried and screened. According to hot storage stability test,various quality indicators of the products met with the relevant provisions of WDG in China. [Conclusion] The study provides theoretical basis for further popularization and application of orthosulfamuron.
