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当前位置: 首页 > 文章 > 蒙药乌兰温都苏-11丸对自发性高血压大鼠Ang-Ⅱ受体AT1R、AT2R蛋白表达的影响 内蒙古农业大学学报(自然科学版) 2019 (3) 1-6
Position: Home > Articles > 蒙药乌兰温都苏-11丸对自发性高血压大鼠Ang-Ⅱ受体AT1R、AT2R蛋白表达的影响 Journal of Inner Mongolia Agricultural University(Natural Science Edition) 2019 (3) 1-6

蒙药乌兰温都苏-11丸对自发性高血压大鼠Ang-Ⅱ受体AT1R、AT2R蛋白表达的影响

作  者：
孟根杜希;金澈勒格尔;刘肇宁;哈申图雅;金浩伟;包满达日娃;云苏日娜
单  位：
内蒙古国际蒙医医院;内蒙古大学;内蒙古民族大学附属医院;内蒙古医科大学
关键词：
原发性高血压;乌兰温都苏-11丸;AT1R;AT2R
摘  要：
目的:研究乌兰温都苏-11丸对自发性高血压大鼠(SHR)心、肾、血管组织中AT1R、AT2R蛋白表达的影响.方法:SHR大鼠60只和同源相匹配的Wistar Kyoto(WKY)大鼠10只,随机分为模型组、对照组、缬沙坦胶囊组、丹参酮Ⅱ_A硫酸钠注射液组、乌兰温都苏-11丸低、中、高剂量组,每组10只.对照组和模型组给予蒸馏水,缬沙坦胶囊组、蒙药乌兰温都苏-11丸低、中、高剂量组每天同时按相应剂量灌胃药物、丹参酮Ⅱ_A磺酸钠注射液组相应剂量腹腔注射药物.给药治疗4周后,采用蛋白质免疫印迹方法分别检测大鼠心、肾、血管中血管紧张素Ⅱ受体AT1R、AT2R蛋白表达水平.结果:Western blot的检测结果表明乌兰温都苏-11丸干预显著降低SHR大鼠心、肾、血管的血管紧张素Ⅱ受体AT1R蛋白表达水平,同时显著增加血管紧张素Ⅱ受体AT2R蛋白表达水平.结论:乌兰温都苏-11丸治疗能够明显抑制AT1R蛋白表达,并显著激活AT2R蛋白表达.其作用机制可能是可通过拮抗血管紧张素Ⅱ受体AT1R的同时激活血管紧张素Ⅱ受体AT2R调节高血压,对高血压引起的靶器官损伤有一定的防治作用.
作  者：
MENG Genduxi;JIN Chelegeer;LIU Zhaoning;HA Shentuya;JIN Haowei;BAO Mandariwa;YUN Surina;Inner Mongolia Medicine University;Inner MongoliaUniversity;Affiliated Hospital of Inner Monggolia University for the Nationalities;Inner Mongolia International Mongolian hospital;
单  位：
MENG Genduxi%JIN Chelegeer%LIU Zhaoning%HA Shentuya%JIN Haowei%BAO Mandariwa%YUN Surina%Inner Mongolia Medicine University%Inner MongoliaUniversity%Affiliated Hospital of Inner Monggolia University for the Nationalities%Inner Mongolia International Mongolian hospital
关键词：
Essential hypertension;;Wulan WenduSu-11 Pill;;AT1R;;AT2R
摘  要：
objective: To study the effects of Wulan Wendusu-11 pill on the expression of AT1 R and AT2 R proteins in heart,kidney and blood vessels of SHR rats.Methods:Sixty SHR rats and 10 Wistar Kyoto(WKY) rats that matched with each other were randomly divided into model group,control group, valsartan capsule group,tanshinone Ⅱ_Asodium sulfate injection group, Wulan WenduSu-11 pill low,middle and high dose groups,10 in each group.The control group and model group were given distilled water,valsartan capsule group,mongolian medicine Wulan Wendusu-11 pill low,middle, and high dose groups were given corresponding doses of gavage drugs daily, and corresponding doses of tanshinone Ⅱ_A sodium injection group were given intraperitoneally.After 4 weeks,the expression levels of angiotensinⅡ receptor AT1 R and AT2 R in rat heart,kidney and blood vessels were detected by Western blot.Results:Significant downregulation of angiotensinⅡ type 1 receptor protein expression in SHR rats and up-regulation of angiotensin Ⅱtype 2 receptor protein expression.Conclusion:Treatment with Wulan Wendusu-11 pill can significantly inhibit AT1 R protein expression and significantly activate AT2 R protein expression.The mechanism of action may be to exert an antihypertensive effect by antagonizing the angiotensinⅡ receptor AT1 R while activating the angiotensinⅡreceptor AT2 R,It has certain preventive and therapeutic effects on target organ damage caused by hypertension.

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