Expression of COX-2,iNOS Protein in EndometriaI Carcinoma

HUANG Duo-mei1,ZHAO Xia1,WANG Ying-hong1,PAN Xiao-ling2(1 The First Affiliated Hospital,Medical College,Shihezi University,Shihezi, Xinjing 832008,China;2 Medical couege of Shihezi University,Shihezi,Xinjiang 832003,China)

COX-2protein;iNOS protein;endometrial carcinoma;expression;clinical significance;imnmnohistochem-istry

To study the relationship between iNOS,COX-2 protein expression and carcinogenesis and progression of endometrial carcinoma.A specific and sensitive immunohistochemical EnVision assay was used to detect the expression of COX-2 and iNOS in paraffin embedded sections of 55 cases of endometrial carcinoma,24 atypical hyperplasia of endometrium and 20 normal endometrium.Results:The overall positive expression rate of COX-2 was higher than that in atypical hyperplasia of endometrium and normal endometrium,no association between COX-2 expression and myometrium invasion and lymph node involvement was found(P>0.05).The positive expression rate of iNOS was higher than that in atypical hyperplasia of endometrium iNOS positive rate was significantly higher in those cases that myometrium invasion with invasion exceeding 1/2 than those without invasion or with invasion not exceeding 1/2.Conclusion:The expression of COX-2 and iNOS in endometrial carcinoma is related to onset and progression of the disease.