Tian JiaYuan;Luo QingChun;Hang Liang;Xiaohong Che

School of Bioengineering,Xihua University,Chengdu Sichuan 610039,China;School of Bioengineering,Xihua University,Chengdu Sichuan 610039,China)

chalcone analogues;antifungal activity.;compounds;product;antifungal activity;a

[Objective] To synthesize chalcone analogues and study their antifungal activity so as to find high-efficient and safe compounds with antifungal activity.[Method] With benzoyl chloride compounds and amines as the materials,16 chalcone analogues were designed and synthesized through the aminolysis reaction of acyl chloride,and their molecular structures were determined by IR and 1H NMR.[Result] The chalcone analogues had certain antifungal activity.The antifungal rate of 100 mg/L compound A2(2-chloro-N-phenyl benzamide) against Rhizoctonia solani and Sclerotiua sclerotiorum reached 90.27% and 92.56%,respectively.[Conclusion] Product A2 was an analogue of the natural product chalcone that could naturally degrade without causing environmental pollution.What's more,its chemical structure was simple and easy to prepare.Using A2 as a lead compound,new high-efficient and low-toxic antifungal agents which were safe to the non-target organisms could be developed through optimizing its chemical structure and studying the relationship between structure and activity.