Quantitative Evaluation of the Regulatory Effect of Cordyceps militaris on Human Body with the Intercellular Directed Weighted Communication Networks

MA Lina;PANG Guangchang;SUN Yong;CUI Zhenfu;School of Science, Tianjin University of Commerce;China Institute for Actuarial Science, Central University of Finance and Economics;College of Biotechnology and Food Science, Tianjin University of Commerce;Beijing Academy of Food Sciences;Beijing Oriental Institute of Measurement and Testing;

directed weighted graph;;intercellular wireless communication networks;;Cordyceps militaris;;cytokines;;degree;;weight

Based on the directed weighted graph, three intercellular wireless communication networks are constructed, which are generated in young and healthy volunteers consuming Cordyceps militaris at low, medium and high doses. The quantitative analyses on three intercellular networks are conducted by means of statistics. It is proved that these parameters can quantitatively describe the conditions, properties, structures and functions of networks from different perspectives. These wireless communication networks have a hierarchical structure, and demonstrate a certain robustness. Meanwhile, different doses of Cordyceps militaris can change the importance and role of the cells during the wireless communications. The consumption of Cordyceps militaris mainly plays a role in down-regulating the intercellular wireless communication network in vivo. Therefore, Cordyceps militaris has good health protection and anti-inflammatory effect on metabolic syndrome(MS) and cardiovascular or cerebrovascular diseases caused by allergic reaction and overnutrition. The middle dose exerts the greatest effect from an average viewpoint. When further increasing the dose, the functional strength is contrarily lowered down. This shows that Cordyceps militaris at various doses has nonlinear and dual-direction regulatory functions on organisms.