当前位置: 首页 > 文章 > 复方中药涂膜剂蛇床子素体外透皮效果观察 金陵科技学院学报 2007,23 (3) 116-118
Position: Home > Articles > The Cattle Skin Penetration Results of Osthole Balm in Vitro Journal of Jinling Institute of Technology 2007,23 (3) 116-118

复方中药涂膜剂蛇床子素体外透皮效果观察

作  者:
陆广富;戴鼎震;陈钟鸣;张志成;杜改梅
单  位:
金陵科技学院动物科学与技术学院;江苏畜牧兽医职业技术学院
关键词:
蛇床子素;涂膜剂;透皮
摘  要:
评价了复方蛇床子涂膜剂经奶牛皮肤的体外效果,将制备的复方蛇床子涂膜剂置于牛皮表皮上方透皮装置的给药室,用HPLC法测定涂抹剂中的蛇床子素的透皮效果。蛇床子素经牛皮渗透到表皮下层的接受池。接受池为40%乙醇。整个装置放置于39oC恒温环境。每小时取接受液3 mL,同时补充3 mL 40%乙醇,连续取样12 h。所取样品按已确立的色谱条件进样5μL,测定蛇床子素的含量。结果蛇床子素的经皮渗透近似于零级动力学特征,表明该透皮剂具备明显的透皮效果。
译  名:
The Cattle Skin Penetration Results of Osthole Balm in Vitro
作  者:
LU Guang-fu1,DAI Ding-zhen2,CHEN Zhong-ming2,ZHANG Zhi-cheng2, DU Gai-mei2 (1.Jiangsu Animal Husbandry and Veterinary College,Taizhou 225700,China;2.Jinling Institute of Technology,Nanjing 210085,China)
关键词:
osthole;balm;skin penetration
摘  要:
Objective:The experiment estimated the cattle skin penetration results of osthole in Fructus cnidii balm in vitro.Methods: Osthole balm was made and put in a modified Franz-diffusion device,which was in constant 39℃ penetrating amount of osthole was determined by HPLC.Osthole penetrated into receipt pool of surface skin,receipt liquid was taken and substituted with 3ml 40% ethanol every hour during the 12 hours experiment period.According to the determined condition of HPLC,5ul of sample was injected to detect the amount of osthole.Results: The process of skin penetration of osthole was according with zero-order kinetics and suggested that the balm have good skin penetration results.

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