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当前位置: 首页 > 文章 > IL-18在妊娠早期大鼠下丘脑视前区核团的表达 动物医学进展 2012,33 (11) 70-73
Position: Home > Articles > Expression of IL-18 in Nuclear Hypothalamus-area of Early Pregnant Rats Progress in Veterinary Medicine 2012,33 (11) 70-73

IL-18在妊娠早期大鼠下丘脑视前区核团的表达

作  者：
杜秋婉;司丽芳;顾琨涛;赵鹏;陈树林
单  位：
河南科技大学动物科技学院;西北农林科技大学动物医学院
关键词：
下丘脑;IL-18;胚泡植入
摘  要：
为系统研究IL-18在胚泡植入前后期大鼠下丘脑中的表达,分别对胚泡植入前后期妊娠大鼠进行取材,固定后用免疫组化SP法,图像分析法进行研究。结果表明,IL-18在胚泡植入前后期大鼠下丘脑均有表达,主要表达于下丘脑视前室周核、视前大细胞核、视上核、视前内侧核、弓状核、视交叉上核、视前外侧核。与植入前期相比,植入后期妊娠大鼠下丘脑视前室周核、视前大细胞核、视上核、视前内侧核、弓状核、视交叉上核、视前外侧核的表达显著高于植入前期(P<0.05),下丘脑视前外侧核的表达极显著高于植入前期(P<0.01)。IL-18与胚泡植入密切相关,可能是IL-18通过下丘脑的反馈途径参与了妊娠调控,其表达变化与妊娠的建立和维持有关,在妊娠中起重要作用。
译  名：
Expression of IL-18 in Nuclear Hypothalamus-area of Early Pregnant Rats
作  者：
DU Qiu-wan1,SI Li-fang1,GU Kun-tao1,ZHAO Peng1,CHEN Shu-lin2(1.College of Animal Science and Technology,Henan University of Science and Technology Luoyang,Henna,471003,China; 2.College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi,712100,China)
关键词：
hypothalamus;IL-18;blastocyst implantation
摘  要：
Thi ultrasensitive immunohistochemistry SP method and image analysis were used to investigate the expression of interleukin-18(IL-18) in fixed rat hypothalamus in pre-implantation period and post-implantation period.The results showed that IL-18 expressed in rat hypothalamus in both pre-implantation period and post-implantation period,mainly expressed in the hypothalamic periventricular nucleus,supraoptic nucleus,preoptic large nucleus,medial preoptic nucleus,lateral preoptic nucleus,suprachiasmatic nucleus,arcuate nucleus.Compared with the pre-implantation period,the expression of IL-18 in post-implantation period in hypothalamic periventricular nucleus,supraoptic nucleus,preoptic large nucleus,medial preoptic nucleus,suprachiasmatic nucleus,arcuate nucleus was significantly higher(P<0.05),and extremely significant in hypothalamic preoptic lateral nucleus(P<0.01).The expression of IL-18 was related to establishing and maintaining pregnancy as the expression of IL-18 was closely related to blastocyst implantation,and IL-18 may be participated in regulating rat pregnancy through the endocrine system of hypothalamus.

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