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当前位置: 首页 > 文章 > 大鼠非酒精性脂肪肝模型的建立 黑龙江八一农垦大学学报 2017 (3) 15-19
Position: Home > Articles > Establishment of Nonalcoholic Fatty Liver Disease Model in Rats Journal of Heilongjiang Bayi Agricultural University 2017 (3) 15-19

大鼠非酒精性脂肪肝模型的建立

作  者：
杨威;徐闯;陈媛媛;郑家三;张洪友;夏成
单  位：
黑龙江八一农垦大学动物科技学院
关键词：
高脂饮食;非酒精性脂肪肝;丙硫氧嘧啶;去氧胆酸盐;盐酸四环素
摘  要：
利用不同高脂饲料配方建立大鼠非酒精性脂肪肝病(NAFLD)模型,为非酒精性脂肪肝的研究提供参考依据。大鼠饲喂单纯高脂饲料以及分别含有去氧胆酸、丙基硫氧嘧啶的高脂高胆固醇饲料,经6周的实验周期。结果显示,单纯饲喂高脂饲料大鼠(H6)呈现出显著的体重增加以及肝脏脂肪浸润。饲喂添加去氧胆酸盐的高脂饲料后大鼠肝脏胆固醇水平显著降低,但血液丙氨酸转氨酶(ALT)和丙氨酸转氨酶(AST)水平显著高于H6大鼠。丙基硫氧嘧啶介导甲状腺机能减退脂肪肝模型(HP6)组大鼠呈现前期体重生长缓慢后期的体重减轻且高的血清甘油三酯(TC)、低密度脂蛋白胆固醇(LDL-c)、ALT。四环素刺激下的甲状腺机能减退大鼠(HPT6)呈现严重肝脏病变以及低下肝脏脂肪蓄积和高水平的血清ALT。表明HP6大鼠存在进行性非酒精性脂肪肝的发生。而在四环素刺激下,甲状腺机能减退大鼠存在进行性肝纤维化以及肝脏疾病晚期的可能。为非酒精性脂肪肝研究提供了有力的基础数据。
译  名：
Establishment of Nonalcoholic Fatty Liver Disease Model in Rats
作  者：
Yang Wei;Xu Chuang;Chen Yuanyuan;Zheng Jiasan;Zhang Hongyou;Xia Cheng;College of Animal Science and Technology,Heilongjiang Bayi Agriculture University;
关键词：
high-fat diet;;nonalcoholic fatty liver disease;;propylthiouracil;;deoxycholic acid;;tetracycline
摘  要：
To study nonalcoholic fatty liver disease(NAFLD),wistar rats were fed with different high-fat diets to develop NAFLD.In this study,wistar rats were fed with high-fat diets(with or without deoxycholic acid or propylthiouracil)for 6 weeks.Our results showed that rats fed a high-fat diet(H6)gained a significant amount of weight and severe steatosis.Compared with H6 rats,rats which fed with high-fat diets with deoxycholic acid showed decreased liver cholesterol and significant higher serum alaninetransaminase(ALT)and aspartate aminotransferase(AST).The hypothyroid rats induced by propylthiouracil had a fleshless body,significantly higher concentrations of total cholesterol(TC),low-density lipoprotein cholesterol(LDL-c)and ALT concentrations in serum.Hypothyroid rats that had a previous prepared with tetracycline demonstrated severe pathological changes in the liver,lower liver triglyceride accumulation and high serum ALT concentrations.The results suggested that propylthiouracil-induced hypothyroidism played an important role in progressive NAFLD,Hypothyroid rats that had a previous prepared with tetracycline could develop an end-stage liver disease.This find was important for NAFLD research.

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