单 位：
安徽省华祥农药化工公司;郑州大学化学系;信阳职业技术学院
摘 要：
报道了以氯甲酸甲酯和2-甲氧羰基-3-氨基磺酰基噻吩为起始原料合成除草剂噻磺隆的方法。原料2-甲氧羰基-3-氨基磺酰基噻吩与氯甲酸甲酯生成2-甲氧羰基-3-甲氧羰基氨基磺酰基噻吩,再与2-氨基-4-甲氧基-6-甲基均三嗪反应生成噻磺隆。避免了异氰酸酯路线的种种缺点,具有收率高、含量高、成本低的特点。以2-甲氧羰基-3-氨基磺酰基噻吩计,总收率为77.73%,原药纯度达93.6%。
译 名：
Synthesis of Herbicide Thifensulfuron
作 者：
LU Yang1, 2, LI Chun-ren3, CHI Hui4, TAO Jing-zhao1, ZHANG Zhi-rong4 (1. Chemistry Department of Zhengzhou University, Zhengzhou 450001, China; 2. Xinyang Agriculture College, Henan Xinyang 464000, China; 3. Chemical Engineering Department of Xinyang Vocational and Technical College, Henan Xinyang 464000, China; 4. Anhui Province Huaxiang Pesticides Chemical Engineering Company, Hefei 230041, China)
关键词：
thifensulfuron; methyl chloroformate; sulfonylureas; herbicide
摘 要：
A method for preparation of thifensulfuron from methyl chloroformate and 2-methoxycarbonyl-3- aminosulfonylthiophene as starting material was reported. 2-Methoxycarbonyl-3-aminosulfonylthiophene reacts with methyl chloroformate to give 2-methoxycarbonyl-3-methoxycarbonyl aminosulfonylthiophene. Thifensulfuron will be obtained by the reaction of the above product and 2-amino-4-methoxy-6-methyl-1,3,5-triazine. This is an economical method to prepare thifensulfuron in high yield and good purity, avoiding the shortcoming of the isocyanate route. The total yield reaches 77.73% based on 2-methoxycarbonyl-3-aminosulfonylthiophene and the purity is 93.6%.
