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Position: Home > Articles > Characterization and synthesis of three impurities in tembotrione Chinese Journal of Pesticide Science 2019 (2) 233-237

环磺酮原药中3个杂质结构的确定及其合成

作  者:
黄朋勉;周智慧;吴鸿;周玲;丁慧;伍斌;赵东江;黄超群
单  位:
长沙嘉桥生物科技有限公司;长沙理工大学化学与食品工程学院
关键词:
环磺酮;杂质;合成;机理研究
摘  要:
采用文献中报道的环磺酮的合成工艺合成了环磺酮原药,通过高效液相色谱分析,发现其原药中含有3个质量分数分别大于0.1%的杂质;通过核磁共振氢谱(1H NMR)及高分辨质谱(HRMS)对3个杂质的结构进行了确证,同时进行了合成。根据合成工艺路线,对该杂质产生的途径进行了分析。
译  名:
Characterization and synthesis of three impurities in tembotrione
作  者:
HUANG Pengmian;ZHOU Zhihui;WU Hong;ZHOU Ling;DING Hui;WU Bin;ZHAO Dongjiang;HUANG Chaoqun;School of Chemistry and Food Engineering, Changsha University of Science & Technology;Changsha Jiaqiao Biotech Co., Ltd.;
关键词:
tembotrione;;impurities;;synthesis;;mechanism study
摘  要:
Tembotrione was prepared according to the reported method. Three main impurities over 0.1% were detected by high-performance liquid chromatography(HPLC). The structures of those impurities were characterized by ~1H NMR and high resolution mass spectrometer(HRMS). Then the impurities were synthesized. The produced pathways of impurities were also analyzed according to the synthetic route.

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